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- bs-1360R-BF594
- 2025年09月30日
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100ul
| 产品编号 | bs-1360R-BF594 |
| 英文名称 | GADD45A Rabbit pAb, BF594 conjugated |
| 中文名称 | BF594标记的生长抑制DNA损伤基因45抗体 |
| 英文别名 | Growth Arrest And DNA Damage Inducible alpha; DNA Damage-Inducible Transcript 1 Protein; DDIT-1; GADD45; DDIT1; Growth Arrest And DNA Damage-Inducible Protein GADD45 alpha; Growth Arrest And DNA-Damage-Inducible 45 alpha; Growth Arrest And DNA-Damage-Inducible, alpha; DNA Damage-Inducible Transcript-1; GA45A_HUMAN |
| 产品应用 | Flow-Cyt=3ug/Test, IF=1:100-500, ICC/IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human GADD45 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Epigenetics and Nuclear Signaling > DNA / RNA > DNA Damage & Repair > Base Excision Repair |
| 亚基 | Interacts with MAPK14. Predominantly monomeric but also forms dimers and other oligomers as concentration increases. Interacts with GADD45GIP1. Interacts weakly with PCNA. Interacts with AURKA, likely to compete with dimerization. |
| 亚细胞定位 | Nucleus. |
| 相似性 | Belongs to the GADD45 family. |
| 功能 | In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity. Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53 dependent and independent mechanisms. |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {3ug/Test} |
| {IF} | {1:100-500} |
| {ICC/IF} | {1:100-500} |
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文献和实验相关实验
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A (2006) Polymyxin B-conjugated alpha 2-macroglobulin as an adjunctive therapy to sepsis: Modes of action and impact on lethality J Pharmacol Exp Ther 318: 762-771 Elsharawy A, Manaster C, Teuber M, Rosenstiel P, Kwiatkowski R, Huse K, Platzer M
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GADD45A Rabbit pAb, BF594 conjugated(bs-1360R-BF594)-100ul
￥2980
