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- bs-10054R-PerCP-Cy7
- 2025年09月30日
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100ul
| 产品编号 | bs-10054R-PerCP-Cy7 |
| 英文名称 | GPR48 Rabbit pAb, PerCP-Cy7 conjugated |
| 中文名称 | PerCP-Cy7标记的G蛋白偶联受体48抗体 |
| 英文别名 | G protein coupled receptor 48; G-protein coupled receptor 48; GPR48; GPCR GPR48; Leucine-rich repeat-containing G protein-coupled receptor 4; Leucine-rich repeat-containing G-protein coupled receptor 4; LGR4; LGR4_HUMAN. |
| 产品应用 | Flow-Cyt=2μg/Test Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human LGR4 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA and 0.02% Proclin300. |
| 研究领域 | Signal Transduction > Signaling Pathway > G Protein Signaling > GPCR |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein. |
| 组织特异性 | Expressed in multiple steroidogenic tissues: placenta, ovary, testis and adrenal. Expressed also in spinal cord, thyroid, stomach, trachea, heart, pancreas, kidney, prostate and spleen. |
| 相似性 | Belongs to the G-protein coupled receptor 1 family. Contains 15 LRR (leucine-rich) repeats. Contains 1 LRRNT domain. |
| 功能 | Orphan receptor. |
| 保存条件 | Store at 2-8°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | G protein-coupled receptors (GPCRs), also designated seven transmembrane (7TM) receptors or heptahelical receptors, interact with G proteins (heterotrimeric GTPases) to synthesize intracellular second messengers, such as diacylglycerol, cyclic AMP, inositol phosphates and calcium ions. Their diverse biological functions range from vision and olfaction to neuronal and endocrine signaling and are involved in many pathological conditions. LGR4 (leucine-rich repeat-containing G protein-coupled receptor 4), also known as GPR48, is a 951 amino acid multi-pass membrane protein that contains 15 LRR (leucine-rich repeats) and belongs to the GPCR family. Expressed in multiple tissues, including testis, ovary, placenta, stomach, heart, kidney, pancreas and spleen, LGR4 functions as an orphan receptor that may be involved in physiologic activities throughout the cell. LGR4 is overexpressed in various cancer types and is thought to enhance carcinoma invasiveness and metastasis, suggesting an important role in tumor progression. |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {2μg/Test} |
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文献和实验Fluorochrome Absorption and Emission Spectra
. Using a 650 nm longpass filter will give optimum detection for this fluorochrome. The emitted light is collected in the fluorescence-3 (FL3) channel. PerCP-Cy5.5 is recommended for use with stream-in-air flow cytometers. APC-Cy7
Fluorochrome Absorption and Emission
. Using a 650 nm longpass filter will give optimum detection for this fluorochrome. The emitted light is collected in the fluorescence-3 (FL3) channel. PerCP-Cy5.5 is recommended for use with stream-in-air flow cytometers. APC-Cy7
4 T细胞富集试剂盒分选CD4+细胞。在日常分选中此法可纯度可达90%以上。细胞随后经FITC标记CD25和PE标记CD127，PerCP或PE-CY7标记CD4抗体进行染色。细胞在BD FACSAria™ 分选型流式细胞仪上进行分选。运用图2所示的设门方法分别分选CD127hiCD25int-lo和CD127loCD25hi-int两个细胞群体。分选细胞经FoxP3染色发现CD127loCD25hi-int细胞表达FoxP3，而CD127hiCD25int-lo群体则完全没有信号（图2B
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