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- bs-10054R-PE
- 2026年05月27日
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100ul
| 产品编号 | bs-10054R-PE |
| 英文名称 | GPR48 Rabbit pAb, PE conjugated |
| 中文名称 | PE标记的G蛋白偶联受体48抗体 |
| 英文别名 | G protein coupled receptor 48; G-protein coupled receptor 48; GPR48; GPCR GPR48; Leucine-rich repeat-containing G protein-coupled receptor 4; Leucine-rich repeat-containing G-protein coupled receptor 4; LGR4; LGR4_HUMAN. |
| 产品应用 | Flow-Cyt=2μg/Test Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human LGR4 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Signal Transduction > Signaling Pathway > G Protein Signaling > GPCR |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein. |
| 组织特异性 | Expressed in multiple steroidogenic tissues: placenta, ovary, testis and adrenal. Expressed also in spinal cord, thyroid, stomach, trachea, heart, pancreas, kidney, prostate and spleen. |
| 相似性 | Belongs to the G-protein coupled receptor 1 family. Contains 15 LRR (leucine-rich) repeats. Contains 1 LRRNT domain. |
| 功能 | Orphan receptor. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | G protein-coupled receptors (GPCRs), also designated seven transmembrane (7TM) receptors or heptahelical receptors, interact with G proteins (heterotrimeric GTPases) to synthesize intracellular second messengers, such as diacylglycerol, cyclic AMP, inositol phosphates and calcium ions. Their diverse biological functions range from vision and olfaction to neuronal and endocrine signaling and are involved in many pathological conditions. LGR4 (leucine-rich repeat-containing G protein-coupled receptor 4), also known as GPR48, is a 951 amino acid multi-pass membrane protein that contains 15 LRR (leucine-rich repeats) and belongs to the GPCR family. Expressed in multiple tissues, including testis, ovary, placenta, stomach, heart, kidney, pancreas and spleen, LGR4 functions as an orphan receptor that may be involved in physiologic activities throughout the cell. LGR4 is overexpressed in various cancer types and is thought to enhance carcinoma invasiveness and metastasis, suggesting an important role in tumor progression. |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {2μg/Test} |
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文献和实验。 蛋白分子量 β-actin蛋白质的标准序列375个氨基酸，理论分子量约42kDa，实际蛋白分子量约48kDa。 亚细胞定位 β-actin主要分布于细胞质中，是构成细胞质内微丝网络的核心组分，通过聚合形成的纤维结构支撑细胞形态、介导细胞运动及物质转运，同时参与细胞质内信号通路的分子互作。除细胞质外，β-actin可通过核转运机制进入细胞核，在核内参与染色质重塑、转录调控及DNA损伤修复过程，其核内分布水平可受细胞周期及病理状态调控，与细胞增殖、分化及凋亡等核心生命活动密切相关。 组织分布 β
（Ubiquitin）是一段仅76个氨基酸的保守小分子蛋白，广泛存在于真核生物体内。泛素化修饰依靠一套三级酶促级联反应完成：E1泛素激活酶活化泛素，传递给E2泛素结合酶，最终由E3泛素连接酶将泛素共价连接到底物蛋白的赖氨酸位点。而细胞内的去泛素化酶（DUB）可随时剪切泛素链，让整个修饰过程保持动态可逆。 图：泛素蛋白酶体系统示意图 Cockram PE, et al. Cell Death Differ. 2021 Feb;28(2):591-605. 长久以来很多人存在认知误区：泛素化只负责介导蛋白
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