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- Bioss
- bs-5760R-BF594
- 2025年09月30日
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100ul
| 产品编号 | bs-5760R-BF594 |
| 英文名称 | PTPN13 Rabbit pAb, BF594 conjugated |
| 中文名称 | BF594标记的Fas相关磷酸酶1抗体 |
| 英文别名 | APO1/CD95(Fas) associated phosphatase; Fas associated phosphatase 1; Protein tyrosine phosphatase non receptor type 13; PTP BAS; PTP BL; DKFZp686J1497; FAP 1; FAP-1; FAP1; Fas associated protein tyrosine phosphatase 1; Fas-associated protein-tyrosine phosphatase 1; HGNC:9646; hPTPE1; PNP 1; PNP1; Protein tyrosine phosphatase 1 Fas associated; protein tyrosine phosphatase 1E; Protein tyrosine phosphatase nonreceptor type 13; Protein tyrosine phosphatase PTPL1; Protein-tyrosine phosphatase 1E; Protein-tyrosine phosphatase PTPL1; PTP E1; PTP-E1; PTP1E; PTPL 1; PTPL1; PTPLE; PTPN 13; FAP1; Tyrosine protein phosphatase non receptor type 13. |
| 产品应用 | Flow-Cyt=3ug/test Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human FAP1/PTPN13 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Cell cycle > Kinases/phosphatases > Phosphatases Cell Biology > Cell Cycle > Kinases/Phosphatases > Phosphatases Signal Transduction > Protein Phosphorylation > Tyrosine Phosphatases |
| 亚基 | Interacts with TRIP6 and TNFRSF6 (Fas receptor) through its second PDZ domain. Interacts with the C-terminal SVP motif of NGFR through its third PDZ domain. Interacts with the LIM domain of PDLIM4 through its second and fourth PDZ domains. Binds PLEKHA1 and PLEKHA2 through its first PDZ domain. Interacts with BRD7 and ARHGAP29. Interacts (via PDZ 3 domain) with PKN2 (via C-terminus). |
| 亚细胞定位 | Cytoplasm, cytoskeleton. Nucleus. Cell projection, lamellipodium. |
| 组织特异性 | Present in most tissues with the exception of the liver and skeletal muscle. Most abundant in lung, kidney and fetal brain. |
| 相似性 | Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. Contains 1 FERM domain. Contains 1 KIND domain. Contains 5 PDZ (DHR) domains. Contains 1 tyrosine-protein phosphatase domain. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | PTPN13 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. This PTP was found to interact with, and dephosphorylate Fas receptor, as well as I-kappa-B-alpha through the PDZ domains, which suggested its role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathway. |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {3ug/test} |
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PTPN13 Rabbit pAb, BF594 conjugated(bs-5760R-BF594)-100ul
￥2980
