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MYF5 Rabbit pAb, Biotin conjug

ated(bs-23876R-Bio)-100ul
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  • ￥2980
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  • bs-23876R-Bio
  • 2025年09月30日
  • 产品信息以Bioss网站为准
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北京博奥森生物技术有限公司
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      100ul

    产品编号bs-23876R-Bio
    英文名称MYF5 Rabbit pAb, Biotin conjugated
    中文名称Biotin标记的生肌决定因子Myf5抗体
    英文别名Myf-5; bHLHc2; Class C basic helix loop helix protein 2; Class C basic helix-loop-helix protein 2; Myf 5; Myf-5; Myf5; MYF5_HUMAN; Myogenic factor 5.
    产品应用IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human MYF5
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Developmental Biology > Organogenesis > Skeletal development > Muscle

    Epigenetics and Nuclear Signaling > Transcription > Domain Families > HLH / Leucine Zipper > Helix-Turn-Helix

    Epigenetics and Nuclear Signaling > Transcription > Transcription Factors

    Stem Cells > Mesenchymal Stem Cells > Myogenesis

    亚基Efficient DNA binding requires dimerization with another bHLH protein.
    亚细胞定位Nucleus.
    相似性Contains 1 bHLH (basic helix-loop-helix) domain.
    功能Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Differentiation of myogenic cells is regulated by multiple positively and negatively acting factors. One well characterized family of helix-loop-helix (HLH) proteins known to play an important role in the regulation of muscle cell development include Myo D, myogenin, Myf-5 and Myf-6 (also designated MRF-4 or herculin). Of interest, most muscle cells express either Myo D or Myf-5 in the committed state, but when induced to differentiate, all turn on expression of myogenin. Myo D transcription factors form heterodimers with products of a more widely expressed family of bHLH genes, the E family, which consists of at least three distinct genes: E2A, IF2 and HEB. Myo D-E heterodimers bind avidly to consensus (CANNTG) E box target sites that are functionally important elements in the upstream regulatory sequences of many muscle-specific terminal differentiation genes.

     

    应用推荐稀释比例
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}

     

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