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- Bioss
- bs-24129R-Bio
- 2025年09月30日
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100ul
| 产品编号 | bs-24129R-Bio |
| 英文名称 | PTH2R Rabbit pAb, Biotin conjugated |
| 中文名称 | Biotin标记的甲状旁腺激素相关受体蛋白2抗体 |
| 英文别名 | Parathyroid hormone 2 receptor; Parathyroid hormone receptor precursor; PTH 2 receptor; PTH2 receptor; Pth2r; PTH2R_MOUSE; Pthr 2; Pthr2. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from mouse PTH2R |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Metabolism > Pathways and Processes > Cofactors, Vitamins / minerals > Vitamins / minerals Neuroscience > Neurotransmission > Receptors / Channels > GPCR > More GPCR Signal Transduction > Growth Factors/Hormones > Hormones Signal Transduction > Metabolism > Vitamins / Minerals |
| 亚基 | Interacts (via N-terminal extracellular domain) with PTHLH and PTH. Homodimer in the absence of bound ligand. Peptide hormone binding leads to dissociation of the homodimer. Interacts (via C-terminus) with the heterodimer formed by GNG2 and GNB1. |
| 亚细胞定位 | Cell membrane. |
| 组织特异性 | Expressed abundantly in brain and pancreas. Also expressed in the testis. |
| 相似性 | Belongs to the G-protein coupled receptor 2 family. |
| 功能 | This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a member of the G-protein coupled receptor 2 family. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013] |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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文献和实验- or triple-labeling immunofluorescence, it is necessary to use primary antibodies raised in different host species such as mouse, rabbit, and goat. However, in many cases, suitable primary antibodies raised in different species are unavailable
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