VIM | Vimentin Rabbit pAb, PerCP-Cy5.5 conj.(bs-0756R-PerCP-Cy5.5)-100ul产品图

VIM | Vimentin Rabbit pAb, Per

CP-Cy5.5 conj.(bs-0756R-PerCP-Cy5.5)-100ul
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  • bs-0756R-PerCP-Cy5.5
  • 2026年10月14日
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    北京博奥森生物技术有限公司
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      100ul

    产品编号bs-0756R-PerCP-Cy5.5
    英文名称Vimentin Rabbit pAb, PerCP-Cy5.5 conjugated
    中文名称PerCP-Cy5.5标记的波形蛋白抗体
    英文别名FLJ36605; OTTHUMP00000019224; VIM; VIME_HUMAN; Vimentin.
    产品应用Flow-Cyt=1μg/Test, ICC/IF=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human Vimentin
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA and 0.02% Proclin300.
    研究领域

    Cancer > Tumor biomarkers

    Developmental Biology > Lineage specification > Ectoderm

    Neuroscience > Cell Type Marker > Neural Stem Cell marker

    Neuroscience > Neurology process > Neurogenesis

    Neuroscience > Neurology process > Neuroregeneration > Neuroregeneration

    Signal Transduction > Antibodies > vimentin

    Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Intermediate Filaments > Class III > Vimentin

    Stem Cells > Lineage Markers > Endoderm

    Stem Cells > Neural Stem Cells > Intracellular

    亚基Homopolymer assembled from elementary dimers. Interacts with HCV core protein. Interacts with LGSN and SYNM. Interacts (via rod region) with PLEC (via CH 1 domain) (By similarity). Interacts with SLC6A4. Interacts with STK33. Interacts with LARP6. Interacts with RAB8B (By similarity).
    亚细胞定位Cytoplasm.
    组织特异性Highly expressed in fibroblasts, somev expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone-independent mammary carcinoma cell lines.
    翻译后修饰Filament disassembly during mitosis is promoted by phosphorylation at Ser-55 as well as by nestin (By similarity). One of the most prominent phosphoproteins in various cells of mesenchymal origin. Phosphorylation is enhanced during cell division, at which time vimentin filaments are significantly reorganized. Phosphorylation by PKN1 inhibits the formation of filaments. Phosphorylated at Ser-56 by CDK5 during neutrophil secretion in the cytoplasm. Phosphorylated by STK33.
    相似性Belongs to the intermediate filament family.
    功能Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.
    Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.
    保存条件Store at 2-8°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract.[provided by RefSeq, Jun 2009]

     

    应用推荐稀释比例
    {Flow-Cyt}{1μg/Test}
    {ICC/IF}{1:100-500}
    {IF}{1:100-500}

     

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