- ￥2980
- Bioss
- bs-1721R-HRP
- 2025年09月30日
- 产品信息以Bioss网站为准
企业认证
相关产品推荐更多 >
GAA Rabbit pAb, BF647 conjugated(bs-13254R-BF647)-100ul
￥2980HSL/LIPE Rabbit pAb, Biotin conjugated(bs-0455R-Bio)-100ul
￥2980
EGFR Rabbit pAb(bs-0165R)-50ul/100ul/200ul
￥1180Angiotensin III Rabbit pAb, PE-Cy5.5 conjugated(bs-20101R-PE-Cy5.5)-100ul
￥2980SARS-CoV N Rabbit pAb, Biotin conjugated(bs-49002R-Bio)-100ul
￥2980
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 应用范围：
产品信息以Bioss网站为准
- 规格：
100ul
| 产品编号 | bs-1721R-HRP |
| 英文名称 | dUTPase Rabbit pAb, HRP conjugated |
| 中文名称 | HRP标记的脱氧尿嘧啶三磷酸核苷水解酶抗体 |
| 英文别名 | Deoxyuridine 5' triphosphate nucleotidohydrolase, nuclear isoform; dUTP pyrophosphatase; dUTPase; FLJ20622; Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial; Deoxyuridine triphosphatase; dut; DUT_HUMAN; dUTP nucleotidohydrolase. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human dUTPase |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Epigenetics and Nuclear Signaling > DNA / RNA > DNA / Nucleotides Epigenetics and Nuclear Signaling > DNA / RNA > DNA Synthesis |
| 亚基 | Homotrimer. |
| 亚细胞定位 | Isoform 2: Nucleus. Isoform 3: Mitochondrion. |
| 组织特异性 | Found in a variety of tissues. Isoform 3 expression is constitutive, while isoform 2 expression correlates with the onset of DNA replication (at protein level). Isoform 2 degradation coincides with the cessation of nuclear DNA replication (at protein level). |
| 翻译后修饰 | Nuclear isoform 2 is phosphorylated in vivo on Ser-11, a reaction that can be catalyzed in vitro by CDC2. Phosphorylation in mature T-cells occurs in a cell cycle-dependent manner. Isoform 3 is not phosphorylated._x000D_
The initiator methionine is cleaved in isoform 2. |
| 相似性 | Belongs to the dUTPase family. |
| 功能 | This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008]. |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
dUTPase Rabbit pAb, HRP conjugated(bs-1721R-HRP)-100ul
￥2980
