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- bs-0581R-AP
- 2026年02月28日
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100ul
| 产品编号 | bs-0581R-AP |
| 英文名称 | IL-4 Rabbit pAb, AP conjugated |
| 中文名称 | AP标记的白介素4抗体 |
| 英文别名 | Interleukin-4; IL4; IL 4; B cell growth factor 1; B cell IgG differentiation factor; B Cell Stimulatory Factor 1; BCGF 1; BCGF1; Binetrakin; BSF 1; BSF1; HCGF; Hodgkin’s Cell Growth Factor; IA Inducing Factor; IGG1 induction factor; Il4e12; Interleukin 4; Interleukin 4, isoform 1; Interleukin4; Lymphocyte stimulatory factor 1; Macrophage fusion factor; Mast cell growth factor 2; MCGF2; MFF; MGC79402; Pitrakinra; T cell growth factor 2; TCGF2; IL4_MOUSE; B-cell stimulatory factor 1; BSF-1. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from mouse IL-4 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Tumor immunology > Cytokines > Interleukins Immunology > Adaptive Immunity > Regulatory T Cells Immunology > Innate Immunity > Cytokines > Interleukins |
| 亚细胞定位 | Secreted. |
| 相似性 | Belongs to the IL-4/IL-13 family. |
| 功能 | Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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文献和实验信号；⑤进一步活化的T细胞更多表达CD401。和分泌细胞因子，其中较重要的如IL-4。与B细胞表面的IL-4R结合．促使B细胞进一步活化并开始增殖分化。参与B激活的其他分子还包括CD30与CD30L(CDl53)、41BB与41BBL、B7-RP与ICOS等，细胞因子IL-5和II．-6则在B细胞激活的后期发挥作用。 图10-7 T细胞与B细胞之间的相互作用图中圆圈内由文字代表第二信号；注意最终生成的抗体是针对抗原B表位(绿色)而非T表位(红色)。2.T、B细胞相互作用的特异性 需要指出
个氨基酸残基不同，在第16位和84位上2个半胱氨酸残基在分子内形成二硫键，此外还有2个N糖基化点 。在体外糖基不影响IL-3的生物学活性。hIL-3启动子上游调控区含有多个转录调控子同源位点，其中AP-1（TGAGTCA）位于-301处，CREB（TTACGTCT）位于-147处，NFAT-1（GATGAATAAT）位于-156处，CK-1（GAAGGTTCCA）位于-126处，CK-2（TCAGATAA）位于-115处。hIL-3转录调控主要受上游两个顺式调控区的调控。第一个位于-121
SDS-PA gels, and subsequent detection of proteins using rabbit antisera and alkaline phosphatase-conjugated goat-anti-rabbit IgG, detected using bromo-chloro-indolyl phosphate (BCIP) and Nitro-blue tetrazolium (NBT) salts. ・
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