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PDIA2 Rabbit pAb, Biotin conju

gated(bs-21441R-Bio)-100ul
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  • ￥2980
  • Bioss已认证
  • bs-21441R-Bio
  • 2025年09月30日
  • 产品信息以Bioss网站为准
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北京博奥森生物技术有限公司
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      100ul

    产品编号bs-21441R-Bio
    英文名称PDIA2 Rabbit pAb, Biotin conjugated
    中文名称Biotin标记的蛋白质二硫键异构酶抗体
    英文别名P4HB; Pancreas specific protein disulfide isomerase; Pancreas-specific protein disulfide isomerase; Pancreatic protein disulfide isomerase; PDA2; PDI; PDIA2; PDIA2_HUMAN; PDIP; PDIR; Protein disulfide isomerase A2; Protein disulfide isomerase; Protein disulfide isomerase associated 2; Protein disulfide isomerase family A member 2; Protein disulfide isomerase pancreatic; Protein disulfide-isomerase A2; Rho GDP dissociation inhibitor gamma.
    产品应用WB=1:500-2000

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human PDIA2
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Cancer Metabolism > Response to hypoxia

    Metabolism > Pathways and Processes > Metabolism processes > Hypoxia

    Tags & Cell Markers > Subcellular Markers > Organelles > ER

    亚基Monomer; predominantly as monomer under reducing conditions. Homodimer; disulfide-linked. Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.
    亚细胞定位Endoplasmic reticulum lumen.
    组织特异性Highly expressed in pancreas (at protein level).
    翻译后修饰The disulfide-linked homodimer exhibits an enhanced chaperone activity.
    Glycosylated._x000D_
    相似性Belongs to the protein disulfide isomerase family._x000D_
    Contains 2 thioredoxin domains._x000D_
    功能Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料The three dimensional structure of many extracellular proteins is stabilized by the formation of disulphide bonds. Studies suggest that a microsomal enzyme known as Protein Disulphide Isomerase (PDI) is involved in disulphide-bond formation and isomerization, as well as the reduction of disulphide bonds in proteins. PDI, which catalyses disulphide interchange between thiols and protein dilsulphides, has also been referred to as thiol:protein-disulphide oxidoreductase and as glutathione:insulin transhydrogenase because of its role in reduction of disulphide bonds. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the carboxy-terminus of PDI and other soluble endoplasmic reticulum (ER) resident proteins including the 78 and 94 kDa glucose regulated proteins (GRP78 and GRP94 respectively). The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.

     

    应用推荐稀释比例
    {WB}{1:500-2000}

     

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