- ￥2980
- Bioss
- bs-8587R-BF555
- 2025年12月08日
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100ul
| 产品编号 | bs-8587R-BF555 |
| 英文名称 | DOK5 Rabbit pAb, BF555 conjugated |
| 中文名称 | BF555标记的胞浆接头蛋白Dok5抗体 |
| 英文别名 | chromosome 20 open reading frame 180; Docking protein 5; DOK 5; DOK5 protein; downstream of tyrosine kinase 5; IRS6; DOK5_HUMAN. |
| 产品应用 | Flow-Cyt=5μg/Test Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human DOK5/IRS6 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Signal Transduction > Adapters > Transmembrane Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > MAPK Pathway Signal Transduction > Protein Phosphorylation > Tyrosine Kinases > Receptor Tyrosine Kinases |
| 亚基 | Interacts with phosphorylated RET. In contrast to other DOK proteins, it does not interact with RASGAP (By similarity). |
| 组织特异性 | Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes. |
| 翻译后修饰 | Phosphorylated on tyrosine residues in response to insulin, IGF1 and GDNF. |
| 相似性 | Belongs to the DOK family. Type B subfamily._x000D_
Contains 1 IRS-type PTB domain._x000D_ Contains 1 PH domain._x000D_ |
| 功能 | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The downstream of kinase family (Dok-1-7) are members of a class of “docking” proteins that include the tyrosine kinase substrates IRS-1 and Cas, which contain multiple tyrosine residues and putative SH2 binding sites. Dok-4 and Dok-5 are more similar to each other than to the other Dok family members, and may constitute a subfamily of the DOK genes. Dok-5 is a tyrosine kinase substrate that enhances c-Ret-dependent activation of mitogen-activated protein kinase (MAPK). Dok-5 transcript is abundant in muscle and increases during T cell activation. Dok-5 protein undergoes tyrosine phosphorylation in response to Insulin and Insulin-like growth factor-1. The gene encoding human Dok-5 maps to chromosomal location 20q13.2. |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {5μg/Test} |
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DOK5 Rabbit pAb, BF555 conjugated(bs-8587R-BF555)-100ul
￥2980
