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Beta-casein Rabbit pAb, AP con

jugated(bs-10032R-AP)-100ul
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  • ￥2980
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  • bs-10032R-AP
  • 2025年10月21日
  • 产品信息以Bioss网站为准
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北京博奥森生物技术有限公司
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    • 规格：

      100ul

    产品编号bs-10032R-AP
    英文名称Beta-casein Rabbit pAb, AP conjugated
    中文名称AP标记的β-酪蛋白抗体
    英文别名beta-casein; Casoparan; Antioxidant peptide; Casohypotensin; CASB; CASB_BOVIN; Casein beta; CSN 2; Csn2; CASB_BOVIN.
    产品应用WB=1:500-2000

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from cow Beta-casein
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Epigenetics and Nuclear Signaling > Transcription > Polymerase associated factors > Pol II Transcription

    Epigenetics and Nuclear Signaling > Transcription > Transcription Factors

    Signal Transduction > Protein Trafficking > Vesicle Transport > Coat Proteins

    亚细胞定位Secreted.
    组织特异性Mammary gland specific. Secreted in milk.
    相似性Belongs to the beta-casein family.
    功能Important role in determination of the surface properties of the casein micelles. _x000D_ Casoparan acts as a macrophage activator, increasing the phagocytic activity of macrophages and peroxide release from macrophages. It also acts as a bradykinin-potentiating peptide. _x000D_ Casohypotensin acts as a bradykinin-potentiating peptide. Induces hypotension in rats. Acts as a strong competitive inhibitor of endo-oligopeptidase A. _x000D_ Antioxidant peptide has antioxidant activity.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Milk proteins are crucial for the development of all newborn mammals and caseins constitute the major proteins in mammalian milk. b- and k-caseins are the only caseins present in human milk. The b-casein/k-casein ratio is higher in colostrum than in transitional and mature milk and is related to a better digestibility of colostrum casein micelles by the neonate during the first days of life. Human b-casein-encoding gene (Bca) contains a highly phosphorylated site, which is responsible for the calcium-binding capacity of b-casein. A common set of transcription factors are required for the expression of b-casein. Multiple binding sites for Stat5, C/EBPb (CCAAT/enchancer-binding protein) and several half-sites for glucocorticoid receptor (GR) are identified in the distal human enhancer of the b-casein gene. b-casein gene transcription is regulated primarily by a composite response element (CoRE), which integrates signaling from the lactogenic hormones PRL, insulin and hydrocortisone in mammary epithelial cells. NFkB functions as a negative regulator of b-casein gene expression during pregnancy by interfering with Stat5 tyrosine phosphorylation

     

    应用推荐稀释比例
    {WB}{1:500-2000}

     

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    • Western 杂交

      SDS-PA gels, and subsequent detection of proteins using rabbit antisera and alkaline phosphatase-conjugated goat-anti-rabbit IgG, detected using bromo-chloro-indolyl phosphate (BCIP) and Nitro-blue tetrazolium (NBT) salts.    ・        

    • Antigen Design Sera Purification Tech Sheet

      for antibody generation. Algorithms for predicting protein characteristics such as hydrophilicity/hydrophobicity and secondary structure regions such as alpha-helix, beta-sheet and beta-turn aid selection of a potentially exposed, immunogenic internal

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