- ￥5800
- Proteintech
- 66797-1-PBS
- 2025年10月09日
- WB, IHC, IF-P, Indirect ELISA
- Mouse
- human, mouse
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- 详细信息
- 技术资料
- 免疫原：
Recombinant human SOCS3 protein
- 亚型：
IgG1
- 保存条件：
Store at -80°C.
- 克隆性：
Monoclonal
- 标记物：
Unconjugated
- 适应物种：
human, mouse
- 宿主：
Mouse
- 应用范围：
WB, IHC, IF-P, Indirect ELISA
- 靶点：
SOCS3
- 抗体英文名：
SOCS3 Monoclonal antibody, PBS Only
- 抗体名：
SOCS3 Monoclonal antibody, PBS Only
- 规格：
100ug
产品信息
66797-1-PBS targets SOCS3 in WB, IHC, IF-P, Indirect ELISA applications and shows reactivity with human, mouse samples.
| 经测试应用 | WB, IHC, IF-P, Indirect ELISA |
| 经测试反应性 | human, mouse |
| 免疫原 |
CatNo: Ag5386 Product name: Recombinant human SOCS3 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 1-225 aa of BC060858 Sequence: MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPPPGAPSFPSPPTEPSSEVPEQPSAQPLPGSPPRRAYYIYSGGEKIPLVLSRPLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL |
| 宿主/亚型 | Mouse / IgG1 |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | suppressor of cytokine signaling 3 |
| 别名 | 1G2B12, ATOD4, CIS3, CIS-3, Cytokine-inducible SH2 protein 3 |
| 计算分子量 | 25 kDa |
| 观测分子量 | 25 kDa |
| GenBank蛋白编号 | BC060858 |
| 基因名称 | SOCS3 |
| Gene ID (NCBI) | 9021 |
| RRID | AB_2882141 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein G purification |
| UNIPROT ID | O14543 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Suppressor of cytokine signaling 3 (SOCS3) is a member of SOCS family that these proteins induced to attenuate cytokine signal transduction in response to signals from a diverse range of cytokines and growth factors. SOCS3 is a negative regulatory protein that inhibits signaling induced by IL-6 via preventing JAK mediated activation of STAT3. However SOCS3 can positively regulate the ERK-MAPK pathway, inhibit the NF-kB pathway (PMID:26429311,25035930). In addition, SOCS3 brings a great impact on immune responses by inhibiting signaling stimulus, such as LPS, type I and type II IFNs, and IL-12. SOCS3 is widely expressed in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney (PMID: 22961088). Dysregulation of SOCS3 functions can cause a variety of diseases, including allergy, autoimmune diseases, inflammation and cancer (PMID:26429311).
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