- ￥1350 - 3000
- Proteintech
- 29186-1-AP
- 2025年10月09日
- WB, ELISA
- Rabbit
- human, mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant human SLC6A4 protein
- 亚型：
IgG
- 保存条件：
Store at -20°C. Stable for one year after shipment.
- 克隆性：
Polyclonal
- 标记物：
Unconjugated
- 适应物种：
human, mouse
- 宿主：
Rabbit
- 应用范围：
WB, ELISA
- 靶点：
Serotonin transporter
- 抗体英文名：
Serotonin transporter Polyclonal antibody
- 抗体名：
Serotonin transporter Polyclonal antibody
- 规格：
50ul/100ul/150ul
| 规格： | 50ul | 产品价格： | ￥1350.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥2200.0 |
| 规格： | 150ul | 产品价格： | ￥3000.0 |
经过测试的应用
| Positive WB detected in | SH-SY5Y cells, RAW 264.7 cells |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:500-1:2000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
29186-1-AP targets Serotonin transporter in WB, ELISA applications and shows reactivity with human, mouse samples.
| 经测试应用 | WB, ELISA |
| 经测试反应性 | human, mouse |
| 免疫原 |
CatNo: Ag30412 Product name: Recombinant human SLC6A4 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-87 aa of NM_001045 Sequence: METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVD |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 |
| 别名 | SLC6A4, 5 HTT, 5 HTTLPR, 5HTT, hSERT |
| 计算分子量 | 70 aa |
| 观测分子量 | 70 kDa |
| GenBank蛋白编号 | NM_001045 |
| 基因名称 | Serotonin transporter |
| Gene ID (NCBI) | 6532 |
| RRID | AB_2935471 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | P31645 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Serotonin transporter (SERT; SLC6A4) belongs to the sodium- and chloride-dependent monoamine transporter family. SERT is a membrane transporter that terminates the neurotransmission of serotonin, a monoaminergic neurotransmitter, through its reuptake. The SERT uptake mechanism acquires energy for active transport via ATP hydrolysis or via movement against electrochemical gradients. As an oligomeric N-glycan, SERT contains disulfide bonds between cysteine residues on the second extracellular domain. Post-translational modifications regulate the uptake kinetics and membrane trafficking of SERT, in part by regulating the proper folding and assembly of SERT in a host-dependent manner (PMID: 30394319).
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文献和实验day−1 for 21 days, tested for anxious response in the light/dark plus maze, then assayed for dopamine and serotonin transporter density by radioligand binding. Exposures to these compounds variably affect dopamine and serotonin transporter density
High-Affinity Binding of Antidepressants to Platelets and Brain Tissues
neuronal serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (noradrenaline, NA) transport. Other radiolabeled antidepreβants whose high-affinity binding sites have been studied in the brain and peripheral tiβues include [3 H]-desipramine, [3 H
. Two of them, the serotonin transporter knockout (SERT−/− ) rat and the dopamine D1 receptor mutant (DRD1−/− ) rat, are described in relation to four important (neurodevelopmental) psychiatric disorders: depression, autism, schizophrenia and drug addiction. It has been shown
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