- ￥5800
- Proteintech
- 82335-1-PBS
- 2025年10月09日
- WB, FC (Intra), Indirect ELISA
- Rabbit
- human, mouse
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 亚型：
IgG
- 保存条件：
Store at -80°C.
- 克隆性：
Recombinant
- 标记物：
Unconjugated
- 适应物种：
human, mouse
- 宿主：
Rabbit
- 应用范围：
WB, FC (Intra), Indirect ELISA
- 靶点：
Phospho-NF-κB p65 (Ser468)
- 抗体英文名：
Phospho-NF-κB p65 (Ser468) Recombinant monoclonal antibody, PBS Only
- 抗体名：
Phospho-NF-κB p65 (Ser468) Recombinant monoclonal antibody, PBS Only
- 规格：
100ug
产品信息
82335-1-PBS targets Phospho-NF-κB p65 (Ser468) in WB, FC (Intra), Indirect ELISA applications and shows reactivity with human, mouse samples.
| 经测试应用 | WB, FC (Intra), Indirect ELISA |
| 文献引用应用 | WB |
| 经测试反应性 | human, mouse |
| 文献引用反应性 | mouse, pig |
| 免疫原 |
fusion protein |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | v-rel reticuloendotheliosis viral oncogene homolog A (avian) |
| 别名 | NFκB (Ser468), NF-κB (Ser468), NF-κB p65 (Ser468), p NF-κB, p NF-κB (Ser468) |
| 计算分子量 | 65 kDa |
| 观测分子量 | 75 kDa |
| GenBank蛋白编号 | BC011603 |
| 基因名称 | NF-κB p65 |
| Gene ID (NCBI) | 5970 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | Q04206 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Nuclear factor kB (NF-kB) is a collective term for a small family of dimeric transcription factors [comprising p65 (RelA) and RelB, c-Rel, p50/p105 (NF-κB1), and p52/p100 (NF-κB2)]. All NF-κB proteins share a Rel homology domain (RHD), which is responsible for DNA binding and dimerization. Only p65, RelB, and c-Rel contain potent transactivation domains within sequences from the C-terminal to the RHD. Exterior signals lead to the phosphorylation and degradation of the inhibitory complex IκB, which is modulated by the IκB kinase (IKK), and its degradation allows for the release of the typical NF-κB heterodimer, p65/p50, to translocate into the nucleus. NF-κB binds to its cognate DNA elements and can transcriptionally activate different target genes among which 200-500 genes have been implicated in cell survival/apoptosis, cell growth, immune response, and inflammation.
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- 作者
- 内容
- 询问日期
文献和实验| Species | Application | Title |
|---|---|---|
| mouse | WB | Neoplasia ZC3H15 suppression ameliorates bone cancer pain through inhibiting neuronal oxidative stress and microglial inflammationAuthors - Li-Quan Huang |
| mouse | WB | J Nanobiotechnology Comprehensive wound healing using ETN@Fe7S8 complex by positively regulating multiple programmed phasesAuthors - Mengxia Chen |
| pig | WB | J Virol Porcine reproductive and respiratory syndrome virus nsp5 inhibits the activation of the Nrf2/HO-1 pathway by targeting p62 to antagonize its antiviral activityAuthors - Fang Wang |
大鼠核因子-κB亚基p65亲和肽(NF-κB p65)酶联免疫分析
大鼠核因子- κB 亚基p65 亲和肽(NF- κB p65) 酶联免疫分析 试剂盒使用说明书 本试剂仅供研究使用 目的：本试剂盒用于测定大鼠血清，血浆及相关液体样本中 核因子- κB 亚基p65 亲和肽(NF- κB p65) 的含量。 实验原理： 本试剂盒应用双抗体夹心法测定标本中 大鼠 核因子- κB 亚基p65 亲和肽(NF- κB p65) 的水平。用纯化的大鼠 核因子- κB 亚基p65
antibody dilution buffer: TBS-T supplemented with2% (w/v) BSA. 6. Antibodies: Phospho-b-catenin Ser33/Ser37/Thr41, phospho-glycogen synthase Ser641, and glycogen synthase (CellSignaling Technologies, Beverly, MA); b-catenin and GSK-3b(BD PharMingen, San
v468. chapter 4 WNT 细胞通路 检测细胞GSK3活性与表达水平
3.1 and 3.6 ). This will provide a “specific activity” measurement relative to total protein in the cell, and is themost accurate measure of total GSK3 activity, or2. Immunoblot using antibodies to phospho-Ser21 (GSK3a)or phospho-Ser9 (GSK3b) (see Sections 3.1 –
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