- ￥5800
- Proteintech
- 85175-5-PBS
- 2025年10月09日
- WB, Indirect ELISA
- Rabbit
- human
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- 详细信息
- 文献和实验
- 技术资料
- 亚型：
IgG
- 保存条件：
Store at -80°C.
- 克隆性：
Recombinant
- 标记物：
Unconjugated
- 适应物种：
human
- 宿主：
Rabbit
- 应用范围：
WB, Indirect ELISA
- 靶点：
Cleaved PARP1 (Asp214)
- 抗体英文名：
Cleaved PARP1 (Asp214) Recombinant monoclonal antibody, PBS Only
- 抗体名：
Cleaved PARP1 (Asp214) Recombinant monoclonal antibody, PBS Only
- 规格：
100ug
产品信息
85175-5-PBS targets Cleaved PARP1 (Asp214) in WB, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, Indirect ELISA |
| 经测试反应性 | human |
| 免疫原 |
fusion protein |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | poly (ADP-ribose) polymerase 1 |
| 别名 | PARP1, ADP-ribosyltransferase diphtheria toxin-like 1, ADPRT, ADPRT 1, ADPRT1 |
| 计算分子量 | 1014 aa, 113 kDa |
| 观测分子量 | 89 kDa |
| GenBank蛋白编号 | BC037545 |
| 基因名称 | PARP1 |
| Gene ID (NCBI) | 142 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | P09874 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
PARP1 (poly(ADP-ribose) polymerase 1) is a nuclear enzyme catalyzing the poly(ADP-ribosyl)ation of many key proteins in vivo. The normal function of PARP1 is the routine repair of DNA damage. Activated by DNA strand breaks, the PARP1 is cleaved into an 85 to 89-kDa COOH-terminal fragment and a 24 kDa NH2-terminal peptide by caspases during the apoptotic process. The appearance of PARP fragments is commonly considered an important biomarker of apoptosis. In addition to caspases, other proteases like calpains, cathepsins, granzymes, and matrix metalloproteinases (MMPs) have also been reported to cleave PARP1 and give rise to fragments ranging from 42-89 kDa.
This antibody only recognizes the cleaved form of PAPR1 but not full-length PARP1.
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文献和实验线粒体荧光探针大全：TMRM，Mitotracker，JC-1
(a few minutes) compared with dyes such as DASPMI (4-Di-1-ASP, D288), which may take 30 minutes or longer.14 Viewed through a fluorescein longpass optical filter (Table 23.12), fluorescence of the mitochondria of cells stained by rhodamine 123 appears yellow
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