- ￥5800
- Proteintech
- 66263-1-PBS
- 2025年10月09日
- WB, IHC, IF/ICC, Indirect ELISA
- Mouse
- human
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- 详细信息
- 技术资料
- 免疫原：
Recombinant human FRS2 protein
- 亚型：
IgG3
- 保存条件：
Store at -80°C.
- 克隆性：
Monoclonal
- 标记物：
Unconjugated
- 适应物种：
human
- 宿主：
Mouse
- 应用范围：
WB, IHC, IF/ICC, Indirect ELISA
- 靶点：
FRS2
- 抗体英文名：
FRS2 Monoclonal antibody, PBS Only
- 抗体名：
FRS2 Monoclonal antibody, PBS Only
- 规格：
100ug
产品信息
66263-1-PBS targets FRS2 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, IHC, IF/ICC, Indirect ELISA |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Ag19299 Product name: Recombinant human FRS2 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 1-300 aa of BC021562 Sequence: MGSCCSCPDKDTVPDNHRNKFKVINVDDDGNELGSGIMELTDTELILYTRKRDSVKWHYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCARAEELFNMLQEIMQNNSINVVEEPVVERNNHQTELEVPRTPRTPTTPGFAAQNLPNGYPRYPSFGDASSHPSSRHPSVGSARLPSVGEESTHPLLVAEEQVHTYVNTTGVQEERKNRTSVHVPLEARVSNAESSTPKEEPSSIEDRDPQILLEPEGVKFVLGPTPVQKQLMEKEKLEQLGRDQVSGSGANNTEWDTGYDSDERRDAPS |
| 宿主/亚型 | Mouse / IgG3 |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | fibroblast growth factor receptor substrate 2 |
| 别名 | SNT, FRS2alpha, FRS2A, FGFR-signaling adaptor SNT, FGFR substrate 2 |
| 计算分子量 | 60 kDa |
| 观测分子量 | 68 kDa |
| GenBank蛋白编号 | BC021562 |
| 基因名称 | FRS2 |
| Gene ID (NCBI) | 10818 |
| RRID | AB_2881650 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | Q8WU20 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Fibroblast growth factor (FGF) receptor substrate 2 (FRS2) has an alternative name as SNT-1, it is an adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. FGF receptor substrates (FRS2 and FRS3) are key adaptor proteins that mediate FGF-FGFR signalling in benign as well as malignant tissue. FRS2 is a 508 amino-acid protein,which is phosphorylated on tyrosine residues. The molecular weight of non-phosphorylated FRS2 is 57-68 kDa, but phosphorylated FRS2 is 80-90 kDa. Phosphorylation of FRS2 is associated with activation of a number of MAP kinases. Allele-specific regulation of FGFR2 mRNA expression with a mildly increased breast cancer risk has been reported.
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