- ￥1610 - 4900
- Proteintech
- 65118-1-Ig
- 2025年10月09日
- FC
- Mouse
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 亚型：
IgG2b, kappa
- 保存条件：
Store at 2-8°C. Stable for one year after shipment.
- 克隆性：
Monoclonal
- 标记物：
Unconjugated
- 适应物种：
Human
- 宿主：
Mouse
- 应用范围：
FC
- 靶点：
CD86
- 抗体英文名：
Anti-Human CD86 (IT2.2)
- 抗体名：
Anti-Human CD86 (IT2.2)
- 规格：
100ug/500ug
| 规格： | 100ug | 产品价格： | ￥1610.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥4900.0 |
经过测试的应用
| Positive FC detected in | human PBMCs |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Flow Cytometry (FC) | FC : 0.2 ug per 10^6 cells in 100 μl suspension |
| This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
65118-1-Ig targets CD86 in FC applications and shows reactivity with Human samples.
| 经测试应用 | FC |
| 经测试反应性 | Human |
| 免疫原 |
fusion protein |
| 宿主/亚型 | Mouse / IgG2b, kappa |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | CD86 molecule |
| 别名 | Activation B7 2 antigen, B7 2, B70, CD28LG2, CD86, CD86 molecule, CTLA 4 counter receptor B7.2, FUN 1, LAB72 |
| 计算分子量 | 329 aa, 38 kDa |
| GenBank蛋白编号 | BC040261 |
| 基因名称 | CD86 |
| Gene ID (NCBI) | 942 |
| ENSEMBL Gene ID | ENSG00000114013 |
| RRID | AB_3084900 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | P42081 |
| 储存缓冲液 | PBS with 0.09% sodium azide, pH 7.3. |
| 储存条件 | Store at 2-8°C. Stable for one year after shipment. |
背景介绍
CD86 (also known as B7-2) is a costimulatory molecule belonging to the immunoglobulin superfamily. Primarily expressed on antigen-presenting cells (APCs), including B cells, dendritic cells, and macrophages, CD86 is the ligand for two proteins at the cell surface of T cells, CD28 antigen and CTLA-4. Binding of CD86 with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of CD86 with CTLA-4 negatively regulates T-cell activation and diminishes the immune response. (PMID: 7513726; 1847722; 11029388; 27591335)
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文献和实验不加NaCl PB离子强度（Mol/L） pH Ig 其他 0.01 8.0 IgG
and the supernatant discarded) twice with Solution A (1.2 M sorbitol, 50 mM KPO4, pH 7). To spheroplast, cells are resupended in 500 ul of Solution A containing 0.1 b-mercaptoethanol, 0.02 glusulase and 5ug/ml zymolyase. The suspension is incubated at 37oC
网络 二、Ig超家族的特点 （一）Ig超家族的结构特点 Ig超家族成员均含有1～7个Ig样结构域，每个Ig样结构域约含70～110个氨基酸残基。其二级结构是两个各含3～5个反平行β折叠股所形成的β片层（anti-parallel β-pleated sheet)平面，每个反平行β折叠股由5～10个氨基酸残基组成，β
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