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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Recombinant human PRKCB protein
- 亚型:
IgG1
- 保存条件:
Store at -20°C. Stable for one year after shipment.
- 克隆性:
Monoclonal
- 标记物:
Unconjugated
- 适应物种:
human, mouse, rat, pig, rabbit
- 宿主:
Mouse
- 应用范围:
WB, ELISA
- 靶点:
PRKCB
- 抗体英文名:
PRKCB Monoclonal antibody
- 抗体名:
PRKCB Monoclonal antibody
- 规格:
50ul/100ul/150ul
| 规格: | 50ul | 产品价格: | ¥1350.0 |
|---|---|---|---|
| 规格: | 100ul | 产品价格: | ¥2200.0 |
| 规格: | 150ul | 产品价格: | ¥3000.0 |
经过测试的应用
| Positive WB detected in | human brain tissue, pig brain tissue, rabbit brain tissue, rat brain tissue, mouse brain tissue |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:2000-1:10000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
68620-1-Ig targets PRKCB in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat, pig, rabbit samples.
| 经测试应用 | WB, ELISA |
| 文献引用应用 | WB, IHC |
| 经测试反应性 | human, mouse, rat, pig, rabbit |
| 文献引用反应性 | human, rat |
| 免疫原 |
CatNo: Ag33693 Product name: Recombinant human PRKCB protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 342-598 aa of BC036472 Sequence: FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHA |
| 宿主/亚型 | Mouse / IgG1 |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | protein kinase C, beta |
| 别名 | PKC beta, 4B7A1, EC:2.7.11.13, pan-PKC, PKC B |
| 计算分子量 | 673 aa, 77 kDa |
| 观测分子量 | 77 kDa |
| GenBank蛋白编号 | BC036472 |
| 基因名称 | PRKCB |
| Gene ID (NCBI) | 5579 |
| RRID | AB_3085312 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein G purification |
| UNIPROT ID | P05771 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. Protein kinase Cs (PKCs) are signaling molecules that play key roles in many cellular processes, including secretion, gene expression, proliferation, and muscle contraction. The PKC family is broadly divided into three subgroups: classical, novel, and atypical PKCs. These subgroups differ in both protein sequences and mechanistic requirements for catalytic activity. PKC beta is one of the PKC family members. PKC beta has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress.
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文献和实验| Species | Application | Title |
|---|---|---|
| WB | Redox Biol Empagliflozin prevents oxidative stress in human coronary artery endothelial cells via the NHE/PKC/NOX axisAuthors - Xiaoling Li | |
| rat | WB,IHC | J Ethnopharmacol Omics-based pharmacological evaluation reveals Yuanhu Zhitong oral liquid ameliorates arthritis by regulating PKC/ERK/NF-κB signaling pathwayAuthors - Kai Zhang |
| human | WB | Acta Pharmacol Sin Madecassoside mitigates acute myocardial infarction injury by activating the PKCB/SPARC signaling pathwayAuthors - Peng Wang |
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