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- 询价
- Signalway Antibody
- 13607
- 2025年09月22日
- WB,ELISA
- Rabbit
- Human;Mouse;Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
The antiserum was produced against synthesized peptide derived from human PLCG1 around the phosphorylation site of Tyr1253. AA range:1221-1270
- 形态：
liquid
- 保存条件：
Store at -20˚C
- 克隆性：
Polyclonal
- 适应物种：
Human;Mouse;Rat
- 保质期：
12 months
- 抗原来源：
Rabbit
- 供应商：
南京赛戈巍生物科技有限公司
- 宿主：
Rabbit
- 应用范围：
WB,ELISA
- 靶点：
Uniprot：P19174
- 抗体英文名：
PLC γ1 (phospho-Tyr1253) Polyclonal Antibody
- 规格：
50ul/100ul
配方:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
应用详情:Western Blot: 1/500 - 1/2000.
ELISA: 1/20000. Not yet tested in other applications.
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文献和实验APCS（SAP）分子特征、免疫调控机制与相关疾病及靶向治疗进展
物）结合后，其五聚体结构会交联细胞膜上的FcγR，导致受体胞内段的ITAM基序被Src家族激酶磷酸化。磷酸化的ITAM随即招募并激活Syk激酶，进而启动包括PLCγ、PI3K-Akt和MAPK在内的多条下游信号级联通路。这些通路的激活最终诱导免疫细胞产生多种效应功能，主要包括：通过肌动蛋白细胞骨架重排介导吞噬作用，清除被APCS调理的靶标；激活NK细胞等效应细胞释放穿孔素和颗粒酶，执行抗体依赖性细胞介导的细胞毒性（ADCC）；以及促进促炎细胞因子的释放。这一过程的最终效应强度，取决于激活型Fc
v468. chapter 4 WNT 细胞通路 检测细胞GSK3活性与表达水平
. Immunoblot using antibodies to phospho-Tyr279/216 can assess alterations in activity independent ofthe N-terminal phosphorylation, although phosphorylation atthis site is most likely to be constitutive (14) . 3. Immunoblot using antibodies to known
secondary antibody were purchased from GIBCO-BRL. Phosphospecific rabbit polyclonal antibodies against 180Thr and 182Tyr dual-phosphorylated p38, against total p38 (phosphorylation state independent), against 204Tyr-phosphorylated ERK1/2 and against total
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