- ￥552
- Sigma-Aldrich
- 进口
- C6643-250MG
- 2025年12月03日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
2-8°C
- 保质期：
根据瓶身LOT号查询
- 英文名：
Clofibrate
- 库存：
有现货
- 供应商：
浙江羽翔生物科技有限公司
- CAS号：
637-07-0
- 规格：
250MG
属性
表单
liquid
质量水平
200
颜色
clear colorless
密度
1.14 g/mL at 25 °C (lit.)
创始人
Wyeth
储存温度
2-8°C
SMILES字符串
CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1
InChI
1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3
InChI key
KNHUKKLJHYUCFP-UHFFFAOYSA-N
基因信息
human ... PPARA(5465)
mouse ... Ppara(19013)
应用
- as a quinolinate phosphoribosyltransferase (QPRT) agonist to study its effects on hepatitis C virus (HCV) infection
- as peroxisome proliferated activated receptor (PPAR) agonist to study its effects on autophagy in rat liver cells
- as a hepatotoxicant to study its effects on gene expression in primary rat hepatocytes
生化/生理作用
特点和优势
包装
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文献和实验Probing the fibrate binding specificity of rat liver fatty acid binding protein.
Liver-fatty acid binding protein (L-FABP) is found in high levels in enterocytes and is involved in cytosolic solubilization of fatty acids. In addition, L-FABP has been shown to bind endogenous and exogenous lipophilic compounds, suggesting that it may also play a role in modulating their absorption and disposition within enterocytes. Previously, we have described binding of L-FABP to a range of drugs, including a series of fibrates. In the present study, we have generated structural models of L-FABP-fibrate complexes and undertaken thermodynamic analysis of the binding of fibrates containing either a carboxylic acid or ester functionality. Analysis of the current data reveals that both the location and the energetics of binding are different for fibrates that contain a carboxylate compared to those that do not. As such, the data presented in this study suggest potential mechanisms that underpin molecular recognition and dictate specificity in the interaction between fibrates and L-FABP.
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