Recombinant HPV52 E7/Protein E
7 Protein (N-His Tag), 重组HPV52E7/Protein E7蛋白 (N端His标签)- ￥1868
- abinScience
- CHINA
- VK424022
- 2026年03月03日
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 保存条件：
Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
- 保质期：
1 year
- 英文名：
Recombinant HPV52 E7/Protein E7 Protein, N-His
- 库存：
999
- 供应商：
abinScience
- 规格：
100ug
| Product name | Recombinant HPV52 E7/Protein E7 Protein, N-His |
|---|---|
| Catalog No. | VK424022 |
| Host species | \ |
| Species reactivity | \ |
| Immunogen | \ |
| Form | Lyophilized |
| Storage buffer | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Purity | >90% as determined by SDS-PAGE. |
| Clonality | \ |
| Isotype | \ |
| Applications | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| Target | \ |
| Purification | \ |
| Endotoxin level | Please contact with the lab for this information. |
| Expression system | E. coli |
| Accession | P36831 |
| Protein length | Met1-Leu99 |
| Nature | Recombinant |
| Observed Molecular Weight | \ |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Alternative Names | Protein E7, E7 |
| Clone ID | \ |
| Species | Human papillomavirus 52 (Human) |
| Product Usage Information | \ |
| Note | For research use only |
abinScience, founded in 2023 in Strasbourg, France, is committed to developing and producing high-quality life science reagents. Rooted in one of Europe’s leading hubs for scientific innovation, abinScience empowers global research through reliable, efficient experimental solutions. Guided by the vision of “Empowering Bioscience Discovery,” we support scientists worldwide in advancing the frontiers of bioscience.
Technology and Innovation
Relying on the global leading position in antibody and protein research and more than 20 years of industry experience of its parent company ProteoGenix since 2003, abinScience has inherited advanced technologies and high-quality standards. In particular, the XtenCHO™ system developed by ProteoGenix, which has two modes of transient expression and stable expression, has been widely recognized as a core technology to improve the efficiency of protein production, providing a solid foundation for ab...
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Application field
Infectious disease research: including viruses, superbugs, parasites, etc.
Neuroscience research: Supporting research on neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.
Immunology research: Covers the research needs of immune activation, inhibition, and allergies and abnormal reactions.
Oncology research: Supporting the development of tumor biology and anti-tumor drugs.
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- 作者
- 内容
- 询问日期
文献和实验• Expression and function of the early activation antigen CD69 in murine macrophages., PMID:9307073
• Expression of early activation antigen (CD69) during human thymic development., PMID:2204504
• Expression of the leukocyte early activation antigen CD69 is regulated by the transcription factor AP-1., PMID:9580241
• CD69, an early activation antigen on lymphocytes, is constitutively expressed by human epidermal Langerhans cells., PMID:1569326
• Induction of the activation-related antigen CD69 on human eosinophils by type IIA phospholipase A2., PMID:10858018
• Ligation of the CD5 or CD28 molecules on resting human T cells induces expression of the early activation antigen CD69 by a calcium- and tyrosine kinase-dependent mechanism., PMID:7682535
• Multiple cis-acting elements regulate the expression of the early T cell activation antigen CD69., PMID:12385031
• T-cell activation in HLA-B8, DR3-positive individuals. Early antigen expression defect in vitro., PMID:7558912
• Characterization of an early activation-dependent antigen on lymphocytes defined by the monoclonal antibody BL-Ac(F2)., PMID:8290889
HPV 并不是宫颈癌唯一的「元凶」？这种微生物化身「帮凶」，共同促进癌症发生
。引人注目的是，在被 HPV E6E7 上调的基因中，28% 的基因在与沙眼衣原体共感染时恢复到与对照相似的表达水平，或者被强烈下调。 其中，E2F 家族成员是最显著的反向调节转录因子。E2F 靶基因被 HPV E6E7 显著上调，但在沙眼衣原体感染后下调。目前尚不清楚这种沙眼衣原体介导的对 HPV E6E7 诱导的 E2F 靶标的抑制将对宿主细胞和病原体产生什么影响。 为了研究两种病原体对 Rb-E2F1 途径的调节，研究人员用沙眼衣原体感染了 hCEcto 类器官和 hCEcto E6E7
Analysis of E7/Rb Associations
of fundamental events, such as cell proliferation and apoptosis. The best-characterized activity of E7 from HPV type 16, the most frequently detected type in cervical cancer, is its ability to bind and induce degradation of the tumor-suppressor retinoblastoma
to target the respective viral mRNAs. E6 silencing induced accumulation of cellular p53 protein, trans activation of the cell cycle control p21 gene, and reduced cell growth. By contrast, E7 silencing induced apoptotic cell death. HPV-negative cells appeared
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