KMN-80

产品名：

KMN-80

品牌：

Absin

货号：

abs47045328

保持条件：

Store at -20℃

浓度：

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免疫原：

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抗原名称：

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应用：

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使用方法：

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产品描述：

The prostaglandin E receptor 4 (EP₄) is one of four G protein-coupled receptors that mediate the actions of prostaglandin E₂ (PGE₂; Item No. 14010). Binding of PGE₂ to the EP₄ receptor causes an increase in intracellular cyclic AMP, which plays important roles in bone formation and resorption, cancer, and atherosclerosis.^1,2,3,4 KMN-80 is a substituted γ-lactam (pyrrolidinone) derivative of PGE₁ (Item No. 13010) that acts as a selective and potent agonist of EP₄ with an IC₅₀ value of 3 nM (IC₅₀ = 1.4 μM for EP₃ and > 10 μM for all other prostanoid receptors).⁵ In functional assays it has been shown to stimulate secreted alkaline phosphatase gene reporter activity in EP₄-transfected HEK293 cells with an EC₅₀ value of 0.19 nM, demonstrating >5,000 and 50,000-fold selectivity against EP₂ and TP, respectively.⁵ KMN-80 can induce the differentiation of bone marrow stem cells from both young and aged rats into osteoblasts in vitro (EC₅₀s = 20 and 153 nM, respectively) and exhibits favorable tolerability up to at least 10 μM, whereas the EP₄ agonist L-902,688 (Item No. 10007712) is highly cytotoxic at similar concentrations in these cells.⁶ KMN-80 has been used to repair calvarial defects in an in vivo rat craniomaxillofacial reconstruction model (rate of reduction in defect size equivalent to BMP-2 treated rats) and to promote bone formation in a rat incisor tooth socket model.⁶

爱必信品牌介绍：

爱必信（上海）生物科技有限公司是一家从事生物学试剂及耗材的高新技术企业。公司秉承“为生命科学创造便利！为客户创造价值！为员工创造幸福人生！”的发展理念，拥有专业的产品研发质检团队、市场营销团队及先进仓储物流等管理团队。荣获2021年度上海市“专精特新”企业称号。

自营品牌Absin®，主要经营产品有：生化试剂（常用生化试剂、生物学实验常用试剂、荧光染料、激动剂/抑制剂，植物提取物）、细胞生物学（细胞培养产品、血清、基质胶、添加剂、检测试剂盒）、免疫学产品、分子生物学产品、实验室仪器/耗材、产品定制和检测服务。

Absin还提供一些独有的特色产品：霍乱毒素B亚单位（CTB）、 鸡胚提取物（CEE）、 牛脑垂体提取物、 呼吸爆发试剂盒、 多色免疫组化试剂盒、 mRNA原料等在业界深受客户喜欢。

Absin秉承踏实，务实，求精和不断创新的精神为中国科学家提供优质产品，努力打造属于中国自己的生物试剂品牌，为广大科学家提供更全面更丰富更优质的产品。

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