- ￥3000 - 6000
- Solarbio|ActivAb
- 北京
- K010730M
- 2025年08月22日
- FCM
- Mouse
- Human
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- 详细信息
- 技术资料
- 亚型：
IgG1
- 保存条件：
Store at 4℃ in dark.Do not freeze.
- 克隆性：
Monoclonal Antibody
- 标记物：
Biotin，Cy3，Cy3.5，Cy5，Cy5.5，Cy7，FITC，HRP，RBITC，Solar Fluor 350，Solar Fluor 405，Solar Fluor 488，Solar Fluor 532，Solar Fluor 555，Solar Fluor 568，Solar Fluor 594，Solar Fluor 633，Solar Fluor 640，Solar Fluor 647，Solar Fluor 660，Solar Fluor 680，Solar Fluor 750
- 适应物种：
Human
- 目录编号：
5175
- 级别：
实验级别
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 宿主：
Mouse
- 应用范围：
FCM
- 浓度：
FCM 5uL/Test.
- 靶点：
CD31
- 抗体英文名：
Anti-CD31(PE-Cy5) Monoclonal Antibody
- 规格：
25T/100T
| 规格： | 25T | 产品价格： | ￥3000.0 |
|---|---|---|---|
| 规格： | 100T | 产品价格： | ￥6000.0 |
| 基本信息 | |
| 英文名称 | Anti-CD31(PE-Cy5) Monoclonal Antibody |
| 宿主 | Mouse |
| 克隆类型 | Monoclonal Antibody |
| 亚型 | IgG1 |
| 交叉反应 | Human |
| 应用 | FCM |
| 稀释比例 | FCM 5uL/Test. |
| 密度 | |
| 靶标 | CD31 |
| 别名 | platelet endothelial cell adhesion molecule precursor-1; PECAM-1; PECAM1; Adhesion molecule; CD31 antigen; CD31 EndoCAM; Endocam; FLJ34100; FLJ58394; GPIIA; Pecam 1; PECA1_HUMAN; PECAM 1 CD31 EndoCAM; PECA1; Pecam1; Platelet endothelial cell adhesion molecule; Platelet/endothelial cell adhesion molecule 1; Adhesion molecule; Platelet/endothelial cell adhesion molecule |
| 背景说明 | This protein is a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions. Type I membrane protein. SIZE: 738 amino acids; 82536 Da. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Long isoform predominates all tissues examined，isoform Delta12 was detected only in trachea and isoform Delta14-15 only in lung，isoform Delta14 was detected in all tissues examined with the strongest expression in heart. PTM: Phosphorylated on Ser and Tyr residues after cellular activation. SIMILARITY: Contains 6 Ig-like C2-type (immunoglobulin-like) domains.CD31，also known as platelet endothelial cell adhesion molecule 1 (PECAM1)，is a type I integral membrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is found on the surface of platelets，monocytes，neutrophils，and some types of T-cells，and makes up a large portion of endothelial cell intercellular junctions. CD31 is implicated in several functions，including transendothelial migration of leukocytes，angiogenesis，and integrin activation. Tyr-690 plays a critical role in leukocyte transendothelial migration (TEM) and is required for efficient trafficking of CD31 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. CD31 prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals，and changes function on apoptosis，promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of CD31 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis，the inside-out signaling of CD31 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte，thus triggering the process of engulfment). CD31 has been used to measure angiogenesis in association with tumor recurrence. Other studies have also indicated that CD31 and CD34 can be used as markers for myeloid progenitor cells and recognize different subsets of myeloid leukemia infiltrates (granular sarcomas). |
| Swiss Prot | P16284 |
| Gene ID | 5175 |
| 亚细胞定位 | Cell membrane |
| 储存条件 | Store at 4℃ in dark.Do not freeze. |
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K010730M Anti-CD31(PE-Cy5) Monoclonal Antibody
￥3000 - 6000
