- ￥480 - 1600
- Solarbio|ActivAb
- 北京
- K116703P
- 2025年08月22日
- IHC
- Rabbit
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant protein of human USP38
- 亚型：
IgG
- 保存条件：
Store at -20℃. Avoid freeze / thaw cycles.
- 克隆性：
Polyclonal Antibody
- 标记物：
Biotin，Cy3，Cy3.5，Cy5，Cy5.5，Cy7，FITC，HRP，RBITC，Solar Fluor 350，Solar Fluor 405，Solar Fluor 488，Solar Fluor 532，Solar Fluor 555，Solar Fluor 568，Solar Fluor 594，Solar Fluor 633，Solar Fluor 640，Solar Fluor 647，Solar Fluor 660，Solar Fluor 680，Solar Fluor 750
- 适应物种：
Human
- 抗原来源：
Recombinant protein of human USP38
- 目录编号：
84640
- 级别：
实验级别
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 宿主：
Rabbit
- 应用范围：
IHC
- 浓度：
IHC 1:50-200.
- 靶点：
USP38
- 抗体英文名：
Anti-USP38 Polyclonal Antibody
- 抗体名：
泛素特异性肽酶38抗体
- 规格：
20ul/50ul/100ul
| 规格： | 20ul | 产品价格： | ￥480.0 |
|---|---|---|---|
| 规格： | 50ul | 产品价格： | ￥960.0 |
| 规格： | 100ul | 产品价格： | ￥1600.0 |
| 基本信息 | |
| 英文名称 | Anti-USP38 Polyclonal Antibody |
| 中文名称 | 泛素特异性肽酶38抗体 |
| 宿主 | Rabbit |
| 克隆类型 | Polyclonal Antibody |
| 亚型 | IgG |
| 交叉反应 | Human |
| 应用 | IHC |
| 稀释比例 | IHC 1:50-200. |
| 密度 | |
| 靶标 | USP38 |
| 别名 | KIAA1891;Deubiquitinating enzyme 38;HP43.8KD;Ubiquitin carboxyl terminal hydrolase 38;Ubiquitin carboxyl-terminal hydrolase 38;Ubiquitin specific peptidase 38;Ubiquitin specific processing protease 38;Ubiquitin thioesterase 38;Ubiquitin thiolesterase 38;Ubiquitin-specific-processing protease 38;UBP38_HUMAN;USP 38;USP38; |
| 背景说明 | Deubiquitinating enzyme that plays a role in various cellular processes， including DNA repair， cell cycle regulation， and immune response (PubMed:22689415， PubMed:30497519， PubMed:31874856， PubMed:35238669). Plays a role in the inhibition of type I interferon signaling by mediating the ’Lys-33’ to ’Lys-48’ ubiquitination transition of TBK1 leading to its degradation (PubMed:27692986). Cleaves the ubiquitin chain from the histone demethylase LSD1/KDM1A and prevents it from degradation by the 26S proteasome， thus maintaining LSD1 protein level in cells (PubMed:30497519). Plays a role in the DNA damage response by regulating the deacetylase activity of HDAC1 (PubMed:31874856). Mechanistically， removes the ’Lys-63’-linked ubiquitin chain promoting the deacetylase activity of HDAC1 in response to DNA damage (PubMed:31874856). Acts also as a specific deubiquitinase of histone deacetylase 3/HDAC3 and cleaves its ’Lys-63’-linked ubiquitin chains to lower its histone deacetylase activity (PubMed:32404892). Regulates MYC levels and cell proliferation via antagonizing ubiquitin E3 ligase FBXW7 thereby preventing MYC ’Lys-48’-linked ubiquitination and degradation (PubMed:34102342). Participates in antiviral response by removing both ’Lys-48’-linked and ’Lys-63’-linked polyubiquitination of Zika virus envelope protein E (PubMed:34696459). Constitutively associated with IL-33R/IL1RL1， deconjugates its ’Lys-27’-linked polyubiquitination resulting in its autophagic degradation (PubMed:35238669). |
| Swiss Prot | Q8NB14 |
| Gene ID | 84640 |
| 亚细胞定位 | Cytoplasm Nucleus |
| 免疫原 | Recombinant protein of human USP38 |
| Public Immunogen Range | 541-883aa |
| 理论分子量 | 113/117kDa |
| EC | |
| 纯化方法 | Affinity purification |
| 储存液 | PBS with 50% Glycerol， 0.03% Proclin300， 0.5% BSA， pH 7.3. |
| 储存条件 | Store at -20℃. Avoid freeze / thaw cycles. |
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文献和实验Polyclonal Antibody Production
, if desired this is best accomplished by Protein A Affinity Chromatography. 上一篇：make an Antibody against a Peptides 下一篇：Immunization Protocol for Monoclonal Antibody Production
Polyclonal Antibody Production
Polyclonal Antibody Production Very useful for rapid and simple generation of antibodies for western blots, ELISA assays, and immunoprecipitation. Rabbit Immunization Initial Preparation Your antigen
a simple ELISA method to detect human anti-antibody response.
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