- ￥480 - 1600
- Solarbio|ActivAb
- 北京
- K116703P
- 2025年08月22日
- IHC
- Rabbit
- Human
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- 详细信息
- 技术资料
- 免疫原：
Recombinant protein of human USP38
- 亚型：
IgG
- 保存条件：
Store at -20℃. Avoid freeze / thaw cycles.
- 克隆性：
Polyclonal Antibody
- 标记物：
Biotin，Cy3，Cy3.5，Cy5，Cy5.5，Cy7，FITC，HRP，RBITC，Solar Fluor 350，Solar Fluor 405，Solar Fluor 488，Solar Fluor 532，Solar Fluor 555，Solar Fluor 568，Solar Fluor 594，Solar Fluor 633，Solar Fluor 640，Solar Fluor 647，Solar Fluor 660，Solar Fluor 680，Solar Fluor 750
- 适应物种：
Human
- 抗原来源：
Recombinant protein of human USP38
- 目录编号：
84640
- 级别：
实验级别
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 宿主：
Rabbit
- 应用范围：
IHC
- 浓度：
IHC 1:50-200.
- 靶点：
USP38
- 抗体英文名：
Anti-USP38 Polyclonal Antibody
- 抗体名：
泛素特异性肽酶38抗体
- 规格：
20ul/50ul/100ul
| 规格： | 20ul | 产品价格： | ￥480.0 |
|---|---|---|---|
| 规格： | 50ul | 产品价格： | ￥960.0 |
| 规格： | 100ul | 产品价格： | ￥1600.0 |
| 基本信息 | |
| 英文名称 | Anti-USP38 Polyclonal Antibody |
| 中文名称 | 泛素特异性肽酶38抗体 |
| 宿主 | Rabbit |
| 克隆类型 | Polyclonal Antibody |
| 亚型 | IgG |
| 交叉反应 | Human |
| 应用 | IHC |
| 稀释比例 | IHC 1:50-200. |
| 密度 | |
| 靶标 | USP38 |
| 别名 | KIAA1891;Deubiquitinating enzyme 38;HP43.8KD;Ubiquitin carboxyl terminal hydrolase 38;Ubiquitin carboxyl-terminal hydrolase 38;Ubiquitin specific peptidase 38;Ubiquitin specific processing protease 38;Ubiquitin thioesterase 38;Ubiquitin thiolesterase 38;Ubiquitin-specific-processing protease 38;UBP38_HUMAN;USP 38;USP38; |
| 背景说明 | Deubiquitinating enzyme that plays a role in various cellular processes， including DNA repair， cell cycle regulation， and immune response (PubMed:22689415， PubMed:30497519， PubMed:31874856， PubMed:35238669). Plays a role in the inhibition of type I interferon signaling by mediating the ’Lys-33’ to ’Lys-48’ ubiquitination transition of TBK1 leading to its degradation (PubMed:27692986). Cleaves the ubiquitin chain from the histone demethylase LSD1/KDM1A and prevents it from degradation by the 26S proteasome， thus maintaining LSD1 protein level in cells (PubMed:30497519). Plays a role in the DNA damage response by regulating the deacetylase activity of HDAC1 (PubMed:31874856). Mechanistically， removes the ’Lys-63’-linked ubiquitin chain promoting the deacetylase activity of HDAC1 in response to DNA damage (PubMed:31874856). Acts also as a specific deubiquitinase of histone deacetylase 3/HDAC3 and cleaves its ’Lys-63’-linked ubiquitin chains to lower its histone deacetylase activity (PubMed:32404892). Regulates MYC levels and cell proliferation via antagonizing ubiquitin E3 ligase FBXW7 thereby preventing MYC ’Lys-48’-linked ubiquitination and degradation (PubMed:34102342). Participates in antiviral response by removing both ’Lys-48’-linked and ’Lys-63’-linked polyubiquitination of Zika virus envelope protein E (PubMed:34696459). Constitutively associated with IL-33R/IL1RL1， deconjugates its ’Lys-27’-linked polyubiquitination resulting in its autophagic degradation (PubMed:35238669). |
| Swiss Prot | Q8NB14 |
| Gene ID | 84640 |
| 亚细胞定位 | Cytoplasm Nucleus |
| 免疫原 | Recombinant protein of human USP38 |
| Public Immunogen Range | 541-883aa |
| 理论分子量 | 113/117kDa |
| EC | |
| 纯化方法 | Affinity purification |
| 储存液 | PBS with 50% Glycerol， 0.03% Proclin300， 0.5% BSA， pH 7.3. |
| 储存条件 | Store at -20℃. Avoid freeze / thaw cycles. |
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K116703P Anti-USP38 Polyclonal Antibody
￥480 - 1600
