- ￥2650 - 4300
- Solarbio|ActivAb
- 北京
- K011479M
- 2025年08月22日
- WB;IHC;IF;ELISA;FCM
- Mouse
- Human;Mouse;Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant protein of human ATF6
- 亚型：
IgG1
- 保存条件：
Store at -20℃.Avoid freeze/thaw cycles.
- 克隆性：
Monoclonal Antibody
- 标记物：
Biotin，Cy3，Cy3.5，Cy5，Cy5.5，Cy7，FITC，HRP，RBITC，Solar Fluor 350，Solar Fluor 405，Solar Fluor 488，Solar Fluor 532，Solar Fluor 555，Solar Fluor 568，Solar Fluor 594，Solar Fluor 633，Solar Fluor 640，Solar Fluor 647，Solar Fluor 660，Solar Fluor 680，Solar Fluor 750
- 适应物种：
Human;Mouse;Rat
- 抗原来源：
Recombinant protein of human ATF6
- 目录编号：
22926
- 级别：
实验级别
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 宿主：
Mouse
- 应用范围：
WB;IHC;IF;ELISA;FCM
- 浓度：
WB 1:5000-50000.IHC 1:250-1000.IF 1:400-1600 FCM 10^6 cells+0.40 ug.
- 靶点：
ATF6
- 抗体英文名：
Anti-ATF6 Monoclonal Antibody
- 抗体名：
活化转录因子6抗体
- 规格：
100ul/50ul
| 规格： | 100ul | 产品价格： | ￥4300.0 |
|---|---|---|---|
| 规格： | 50ul | 产品价格： | ￥2650.0 |
| 基本信息 | |
| 英文名称 | Anti-ATF6 Monoclonal Antibody |
| 中文名称 | 活化转录因子6抗体 |
| 宿主 | Mouse |
| 克隆类型 | Monoclonal Antibody |
| 亚型 | IgG1 |
| 交叉反应 | Human;Mouse;Rat |
| 应用 | WB;IHC;IF;ELISA;FCM |
| 稀释比例 | WB 1:5000-50000.IHC 1:250-1000.IF 1:400-1600 FCM 10^6 cells+0.40 ug. |
| 密度 | |
| 靶标 | ATF6 |
| 别名 | Activating transcription factor 6 alpha;Activating transcription factor 6;ATF 6;ATF6 alpha;ATF6;ATF6-alpha;ATF6A;ATF6A_HUMAN;cAMP dependent transcription factor ATF 6 alpha;cAMP-dependent transcription factor ATF-6 alpha;Cyclic AMP dependent transcription factor ATF 6 alpha;DKFZp686P2194;ESTM49;FLJ21663;Processed cyclic AMP dependent transcription factor ATF 6 alpha;Processed cyclic AMP-dependent transcription factor ATF-6 alpha. |
| 背景说明 | Activating transcription factor 6 (ATF6) is a transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes.Binds DNA on the 5’-CCAC[GA]-3’half of the ER stress response element (ERSE) (5’-CCAAT-N(9)-CCAC[GA]-3’) and of ERSE II (5’-ATTGG-N-CCACG-3’).Binding to ERSE requires binding of NF-Y to ERSE.Could also be involved in activation of transcription by the serum response factor.During unfolded protein response an approximative 50 kDa fragment containing the cytoplasmic transcription factor domain is released by proteolysis.The cleavage seems to be performed sequentially by site-1 and site-2 proteases.The fully glycosylated form of ATF6 a 670 amino acid protein exhibits an electrophoretic mobility of ~90 kDa in denaturing SDS-gels in part because of the glycosylated modifications.ATF6 has 3 consensus sites for N-linked glycosylation and exists constitutively as a glycosylated protein.Differentially glycosylated ATF6 forms may result from mutations or experimental treatment (PMID:15804611) (PMID:14699159).The antibody recognizes cleaved and fully glycosylated forms of ATF6. |
| Swiss Prot | P18850 |
| Gene ID | 22926 |
| 亚细胞定位 | Endoplasmic reticulum membrane Golgi apparatus membrane Nucleus |
| 免疫原 | Recombinant protein of human ATF6 |
| Public Immunogen Range | 1-194aa |
| 理论分子量 | 75kDa |
| 实际分子量 | 90-100kDa |
| EC | |
| 纯化方法 | Affinity purification |
| 储存液 | PBS with 0.02% sodium azide，50% glycerol，pH7.3. |
| 储存条件 | Store at -20℃.Avoid freeze/thaw cycles. |
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文献和实验指仅对一种抗原决定基的纯粹的抗体。这类抗体不可能通过将抗原 胞的 Hybridoma，在试管内制成了纯粹的单克隆抗体。用某种抗原使动物产生免疫感应，对应于抗原之不同部分可制成各种不同的抗体复合体。然而，因为一个产生抗体的细胞，只能产生一种抗体，所以骨髓肿瘤细胞与产生抗体细胞间的细胞杂种，可形成边产生抗体边增殖的 hybridoma，将每个杂种细胞进行克隆（无性繁殖系）培养，则一个克隆的细胞群只由单种类产生同一抗体的细胞所组成，这样得到的就是单克隆抗体。此抗体在测定
Monoclonal Antibody Production
Order 6 six week old Balb/C mice and let the ARC know they are coming.Have your antigen ready for when they arrive.Once they get there earmark the mice and perform a pre-bleed on them to be used as an ELISA control for monitoring the titer
a simple ELISA method to detect human anti-antibody response.
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