- ￥480 - 1600
- Solarbio|ActivAb
- 北京
- K116193P
- 2025年08月22日
- IHC
- Rabbit
- Human;Mouse;Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant protein of human AKT1
- 亚型：
IgG
- 保存条件：
Store at -20℃. Avoid freeze / thaw cycles.
- 克隆性：
Polyclonal Antibody
- 标记物：
Biotin，Cy3，Cy3.5，Cy5，Cy5.5，Cy7，FITC，HRP，RBITC，Solar Fluor 350，Solar Fluor 405，Solar Fluor 488，Solar Fluor 532，Solar Fluor 555，Solar Fluor 568，Solar Fluor 594，Solar Fluor 633，Solar Fluor 640，Solar Fluor 647，Solar Fluor 660，Solar Fluor 680，Solar Fluor 750
- 适应物种：
Human;Mouse;Rat
- 抗原来源：
Recombinant protein of human AKT1
- 目录编号：
207
- 级别：
实验级别
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 宿主：
Rabbit
- 应用范围：
IHC
- 浓度：
IHC 1:50-200.
- 靶点：
AKT1
- 抗体英文名：
Anti-AKT1 Polyclonal Antibody
- 抗体名：
v-akt小鼠胸腺瘤病毒癌基因同源物1抗体
- 规格：
50ul/100ul/20ul
| 规格： | 50ul | 产品价格： | ￥960.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1600.0 |
| 规格： | 20ul | 产品价格： | ￥480.0 |
| 基本信息 | |
| 英文名称 | Anti-AKT1 Polyclonal Antibody |
| 中文名称 | v-akt小鼠胸腺瘤病毒癌基因同源物1抗体 |
| 宿主 | Rabbit |
| 克隆类型 | Polyclonal Antibody |
| 亚型 | IgG |
| 交叉反应 | Human;Mouse |
| 预测交叉反应 | Bovine;Fruit fly |
| 应用 | IHC |
| 稀释比例 | IHC 1:50-200. |
| 密度 | |
| 靶标 | AKT1 |
| 别名 | AKT 1; AKT; AKT1; AKT1_HUMAN; MGC99656; PKB; PKB-ALPHA; PRKBA; Protein Kinase B Alpha; Protein kinase B; Proto-oncogene c-Akt; RAC Alpha; RAC; RAC-alpha serine/threonine-protein kinase; RAC-PK-alpha; Akt2; AKT2_HUMAN; HIHGHH; murine thymoma viral (v-akt) homolog-2; PKB; PKB beta; PKBB; PKBBETA; PRKBB; Protein kinase Akt 2; Protein kinase Akt-2; Protein kinase B beta; rac protein kinase beta; RAC-BETA; RAC-beta serine/threonine-protein kinase; RAC-PK-beta; v akt murine thymoma viral oncogene homolog 2; Akt3; AKT3 kinase; AKT3_HUMAN; DKFZp434N0250; MPPH; PKB gamma; PKBG; PRKBG; Protein kinase Akt-3; Protein Kinase AKT3; |
| 背景说明 | This gene encodes one of the three members of the human AKT serine-threonine protein kinase family which are often referred to as protein kinase B alpha， beta， and gamma. These highly similar AKT proteins all have an N-terminal pleckstrin homology domain， a serine/threonine-specific kinase domain and a C-terminal regulatory domain. These proteins are phosphorylated by phosphoinositide 3-kinase (PI3K). AKT/PI3K forms a key component of many signalling pathways that involve the binding of membrane-bound ligands such as receptor tyrosine kinases， G-protein coupled receptors， and integrin-linked kinase. These AKT proteins therefore regulate a wide variety of cellular functions including cell proliferation， survival， metabolism， and angiogenesis in both normal and malignant cells. AKT proteins are recruited to the cell membrane by phosphatidylinositol 3， 4， 5-trisphosphate (PIP3) after phosphorylation of phosphatidylinositol 4， 5-bisphosphate (PIP2) by PI3K. Subsequent phosphorylation of both threonine residue 308 and serine residue 473 is required for full activation of the AKT1 protein encoded by this gene. Phosphorylation of additional residues also occurs， for example， in response to insulin growth factor-1 and epidermal growth factor. Protein phosphatases act as negative regulators of AKT proteins by dephosphorylating AKT or PIP3. The PI3K/AKT signalling pathway is crucial for tumor cell survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating AKT1 which then phosphorylates and inactivates components of the apoptotic machinery. AKT proteins also participate in the mammalian target of rapamycin (mTOR) signalling pathway which controls the assembly of the eukaryotic translation initiation factor 4F (eIF4E) complex and this pathway， in addition to responding to extracellular signals from growth factors and cytokines， is disregulated in many cancers. Mutations in this gene are associated with multiple types of cancer and excessive tissue growth including Proteus syndrome and Cowden syndrome 6， and breast， colorectal， and ovarian cancers. Multiple alternatively spliced transcript variants have been found for this gene. |
| Swiss Prot | P31749 |
| Gene ID | 207 |
| 亚细胞定位 | Cytoplasm Nucleus |
| 免疫原 | Recombinant protein of human AKT1 |
| Public Immunogen Range | 26-180aa |
| 理论分子量 | 48/56kDa |
| EC | |
| 纯化方法 | Affinity purification |
| 储存液 | PBS with 50% Glycerol， 0.03% Proclin300， 0.5% BSA， pH 7.3. |
| 储存条件 | Store at -20℃. Avoid freeze / thaw cycles. |
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文献和实验Polyclonal Antibody Production
, if desired this is best accomplished by Protein A Affinity Chromatography. 上一篇：make an Antibody against a Peptides 下一篇：Immunization Protocol for Monoclonal Antibody Production
Polyclonal Antibody Production
Polyclonal Antibody Production Very useful for rapid and simple generation of antibodies for western blots, ELISA assays, and immunoprecipitation. Rabbit Immunization Initial Preparation Your antigen
a simple ELISA method to detect human anti-antibody response.
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