- ￥480 - 1600
- Solarbio|ActivAb
- 北京
- K114393P
- 2025年08月22日
- IHC
- Rabbit
- Human;Mouse
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- 详细信息
- 技术资料
- 免疫原：
A synthetic peptide of human DHX58
- 亚型：
IgG
- 保存条件：
Store at -20℃. Avoid freeze/thaw cycles.
- 克隆性：
Polyclonal Antibody
- 标记物：
Biotin，Cy3，Cy3.5，Cy5，Cy5.5，Cy7，FITC，HRP，RBITC，Solar Fluor 350，Solar Fluor 405，Solar Fluor 488，Solar Fluor 532，Solar Fluor 555，Solar Fluor 568，Solar Fluor 594，Solar Fluor 633，Solar Fluor 640，Solar Fluor 647，Solar Fluor 660，Solar Fluor 680，Solar Fluor 750
- 适应物种：
Human;Mouse
- 抗原来源：
A synthetic peptide of human DHX58
- 目录编号：
79132
- 级别：
实验级别
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 宿主：
Rabbit
- 应用范围：
IHC
- 浓度：
IHC 1:50-200.
- 靶点：
DHX58
- 抗体英文名：
Anti-DHX58 Polyclonal Antibody
- 抗体名：
DHX58蛋白
- 规格：
20ul/100ul/50ul
| 规格： | 20ul | 产品价格： | ￥480.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1600.0 |
| 规格： | 50ul | 产品价格： | ￥960.0 |
| 基本信息 | |
| 英文名称 | Anti-DHX58 Polyclonal Antibody |
| 中文名称 | DHX58蛋白 |
| 宿主 | Rabbit |
| 克隆类型 | Polyclonal Antibody |
| 亚型 | IgG |
| 交叉反应 | Human;Mouse |
| 应用 | IHC |
| 稀释比例 | IHC 1:50-200. |
| 密度 | |
| 靶标 | DHX58 |
| 别名 | C75963; Chloride channel Ka; Chloride channel kidney A; Chloride channel protein ClC Ka; Chloride channel protein ClC-Ka; ClC K1; ClC-K1; CLCK1; hClC Ka; MGC61490; MGC93313; RP23-308N2.5; |
| 背景说明 | Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells，or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA，binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1，competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3. Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses and coronavirus SARS-CoV-2，and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA，with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA，although it can recognize RNA lacking a 5'-triphosphate. |
| Swiss Prot | Q96C10 |
| Gene ID | 79132 |
| 亚细胞定位 | Cytoplasm |
| 免疫原 | A synthetic peptide of human DHX58 |
| Public Immunogen Range | 330-380/678aa |
| 理论分子量 | 77kDa |
| EC | |
| 纯化方法 | Affinity purification |
| 储存液 | PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3. |
| 储存条件 | Store at -20℃. Avoid freeze/thaw cycles. |
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K114393P Anti-DHX58 Polyclonal Antibody
￥480 - 1600
