K117767P Anti-PI16 Polyclonal

PI16 (Peptidase Inhibitor 16) is a variable molecular weight (MW) member of the CRISP family of proteins. It is expressed by cardiomyocytes and serves as an autocrine negative growth regulator. Mature mouse PI16 is a type I transmembrane protein 469 amino acids (aa) in length. The extracellular region includes all but the C terminal 21 amino acids. A soluble form of PI16 is known. Although its predicted MW is 50 kDa， it runs anomalously at 70 kDa (unmodified) in SDS-PAGE. With glycosylation， it appears to be 100 110 kDa in size. Three potential variants exist. One shows a deletion of aa 51 124， a second shows a 9 aa extension at the N terminus， and a third shows a deletion of aa 191 452. Over aa 1 464， mouse PI16 shares 86% and 61% aa identity with rat and human PI16， respectively.