K011438P Anti-CXCR6 Polyclonal

【抗体靶点简介】

The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the CXC chemokine receptor family. This family also includes CXCR1，CXCR2，CXCR3，CXCR4，CXCR5，and CXCR7. This gene，which maps to the chemokine receptor gene cluster，is expressed in several T lymphocyte subsets and bone marrow stromal cells. The encoded protein and its exclusive ligand，chemokine ligand 16 (CCL16)，are part of a signalling pathway that regulates T lymphocyte migration to various peripheral tissues (the liver，spleen red pulp，intestine，lungs，and skin) and promotes cell-cell interaction with dendritic cells and fibroblastic reticular cells. CXCR6/CCL16 also controls the localization of resident memory T lymphocytes to different compartments of the lung and maintains airway resident memory T lymphocytes，which are an important first line of defense against respiratory pathogens. The encoded protein serves as an entry coreceptor used by HIV-1 and SIV to enter target cells，in conjunction with CD4.

【实验操作视频参考】

Western blot实验参考操作流程

Immunohistochemistry实验参考操作流程

抗体在科研领域应用十分广泛，对解析生物学过程、探究疾病发病机制、创新药物研发与临床治疗研究均起到关键支撑作用。

索莱宝现有30000余种经过严格实验验证的抗体产品，全面覆盖神经科学、细胞凋亡、表观遗传学等热门研究方向，适配 WB、IHC、ELISA、IP、co-IP 等主流实验技术场景。包括内参标签抗体，以及多种标记类型的一抗、二抗，充分满足客户多样化实验选型需求。索莱宝拥有成熟专业的抗体制备与质量检测平台，从免疫制备、纯化提纯到实验验证全流程严格筛选评估，全方位保障每一支抗体的性能与品质。

此外，索莱宝已完善一站式技术服务平台，可提供 WB、IHC、IF、IP、流式检测、细胞实验等常规检测，以及多克隆/单克隆抗体定制等个性化定制服务，为科研用户提供全方位解决方案。