- ￥480 - 1600
- Solarbio|ActivAb
- 北京
- K109225P
- 2025年08月20日
- IHC
- Rabbit
- Mouse;Human
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- 详细信息
- 技术资料
- 免疫原：
A synthetic peptide of human MAPKAPK2
- 亚型：
IgG
- 保存条件：
Store at -20℃. Avoid freeze/thaw cycles.
- 克隆性：
Polyclonal Antibody
- 标记物：
Biotin，Cy3，Cy3.5，Cy5，Cy5.5，Cy7，FITC，HRP，RBITC，Solar Fluor 350，Solar Fluor 405，Solar Fluor 488，Solar Fluor 532，Solar Fluor 555，Solar Fluor 568，Solar Fluor 594，Solar Fluor 633，Solar Fluor 640，Solar Fluor 647，Solar Fluor 660，Solar Fluor 680，Solar Fluor 750
- 适应物种：
Mouse;Human
- 抗原来源：
A synthetic peptide of human MAPKAPK2
- 目录编号：
9261
- 级别：
实验级别
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 宿主：
Rabbit
- 应用范围：
IHC
- 浓度：
IHC 1:25-100.
- 靶点：
MAPKAPK2
- 抗体英文名：
Anti-MAPKAPK2 Polyclonal Antibody
- 抗体名：
丝裂原活化蛋白激酶活化的蛋白激酶2抗体
- 规格：
20ul/100ul/50ul
| 规格： | 20ul | 产品价格： | ￥480.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1600.0 |
| 规格： | 50ul | 产品价格： | ￥960.0 |
| 基本信息 | |
| 英文名称 | Anti-MAPKAPK2 Polyclonal Antibody |
| 中文名称 | 丝裂原活化蛋白激酶活化的蛋白激酶2抗体 |
| 宿主 | Rabbit |
| 克隆类型 | Polyclonal Antibody |
| 亚型 | IgG |
| 交叉反应 | Mouse;Human |
| 预测交叉反应 | Rabbit(100%);Hamster(100%) |
| 应用 | IHC |
| 稀释比例 | IHC 1:25-100. |
| 密度 | |
| 靶标 | MAPKAPK2 |
| 别名 | MAPKAP Kinase 2 (phospho S222), p-MAPKAP Kinase 2 (phospho S222), 3PK, AA960234, MAP kinase activated protein kinase 2, MAP kinase activated protein kinase 3, MAPK activated protein kinase 2, MAPK activated protein kinase 3, MAPKAP kinase 2, MAPKAP kinase 3, MK2, MK3, MAPK2_HUMAN, |
| 背景说明 | Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X2-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Phosphorylates HSF1; leading to the interaction with HSP90 proteins and inhibiting HSF1 homotrimerization, DNA-binding and transactivation activities. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to the dissociation of HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impairment of their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to the regulation of the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity, leading to inhibition of dependent degradation of ARE-containing transcripts. Phosphorylates CEP131 in response to cellular stress induced by ultraviolet irradiation which promotes binding of CEP131 to 14-3-3 proteins and inhibits formation of novel centriolar satellites. Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilization of GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. |
| Swiss Prot | P49137 |
| Gene ID | 9261 |
| 亚细胞定位 | Cytoplasm |
| 免疫原 | A synthetic peptide of human MAPKAPK2 |
| Public Immunogen Range | 190-240/400aa |
| 理论分子量 | 42/45kDa |
| EC | |
| 纯化方法 | Affinity purification |
| 储存液 | PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3. |
| 储存条件 | Store at -20℃. Avoid freeze/thaw cycles. |
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K109225P Anti-MAPKAPK2 Polyclonal Antibody
￥480 - 1600
