- ￥480 - 1600
- Solarbio|ActivAb
- 北京
- K109421P
- 2025年08月20日
- IHC
- Rabbit
- Mouse;Rat;Human
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- 详细信息
- 技术资料
- 免疫原：
A synthetic peptide of human FYN
- 亚型：
IgG
- 保存条件：
Store at -20℃. Avoid freeze/thaw cycles.
- 克隆性：
Polyclonal Antibody
- 标记物：
Biotin，Cy3，Cy3.5，Cy5，Cy5.5，Cy7，FITC，HRP，RBITC，Solar Fluor 350，Solar Fluor 405，Solar Fluor 488，Solar Fluor 532，Solar Fluor 555，Solar Fluor 568，Solar Fluor 594，Solar Fluor 633，Solar Fluor 640，Solar Fluor 647，Solar Fluor 660，Solar Fluor 680，Solar Fluor 750
- 适应物种：
Mouse;Rat;Human
- 抗原来源：
A synthetic peptide of human FYN
- 目录编号：
2534
- 级别：
实验级别
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 宿主：
Rabbit
- 应用范围：
IHC
- 浓度：
IHC 1:100-300.
- 靶点：
FYN
- 抗体英文名：
Anti-FYN Polyclonal Antibody
- 抗体名：
与 SRC、FGR、YES 相关的 FYN 癌基因抗体
- 规格：
20ul/100ul/50ul
| 规格： | 20ul | 产品价格： | ￥480.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1600.0 |
| 规格： | 50ul | 产品价格： | ￥960.0 |
| 基本信息 | |
| 英文名称 | Anti-FYN Polyclonal Antibody |
| 中文名称 | 与 SRC、FGR、YES 相关的 FYN 癌基因抗体 |
| 宿主 | Rabbit |
| 克隆类型 | Polyclonal Antibody |
| 亚型 | IgG |
| 交叉反应 | Mouse;Rat;Human |
| 预测交叉反应 | Cow(100%);Chicken(100%);Pig(93.3%);Zebrafish(92.3%);Xenopus laevis(93.3%) |
| 应用 | IHC |
| 稀释比例 | IHC 1:100-300. |
| 密度 | |
| 靶标 | FYN |
| 别名 | Fyn, C syn protooncogene, FYN oncogene related to SRC FGR YES, MGC45350, OKT3 induced calcium influx regulator, P59 FYN, Protein tyrosine kinase fyn, Proto oncogene tyrosine protein kinase fyn, Protooncogene Syn, SLK, Src like kinase, Src yes related novel gene, Src/yes related novel gene,SYN, Tyrosine kinase p59fyn T, Tyrosine kinase p59fyn(T), FYN_HUMAN, Tyrosine-protein kinase Fyn, Proto-oncogene Syn, Proto-oncogene c-Fyn, Src-like kinase, p59-Fyn |
| 背景说明 | Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1. In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling. |
| Swiss Prot | P06241 |
| Gene ID | 2534 |
| 亚细胞定位 | Cell membrane Cytoplasm |
| 免疫原 | A synthetic peptide of human FYN |
| Public Immunogen Range | 15-65/537aa |
| 理论分子量 | 54/60/61kDa |
| EC | |
| 纯化方法 | Octanoic acid-ammonium sulfate precipitation |
| 储存液 | PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3. |
| 储存条件 | Store at -20℃. Avoid freeze/thaw cycles. |
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K109421P Anti-FYN Polyclonal Antibody
￥480 - 1600
