- ￥480 - 1600
- Solarbio|ActivAb
- 北京
- K109566P
- 2025年08月20日
- WB
- Rabbit
- Human;Rat;Mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant protein of human FHIT
- 亚型：
IgG
- 保存条件：
Store at -20℃. Avoid freeze/thaw cycles.
- 克隆性：
Polyclonal Antibody
- 标记物：
Biotin，Cy3，Cy3.5，Cy5，Cy5.5，Cy7，FITC，HRP，RBITC，Solar Fluor 350，Solar Fluor 405，Solar Fluor 488，Solar Fluor 532，Solar Fluor 555，Solar Fluor 568，Solar Fluor 594，Solar Fluor 633，Solar Fluor 640，Solar Fluor 647，Solar Fluor 660，Solar Fluor 680，Solar Fluor 750
- 适应物种：
Human;Rat;Mouse
- 抗原来源：
Recombinant protein of human FHIT
- 目录编号：
2272
- 级别：
实验级别
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 宿主：
Rabbit
- 应用范围：
WB
- 浓度：
WB 1:1000-3000.
- 靶点：
FHIT
- 抗体英文名：
Anti-FHIT Polyclonal Antibody
- 抗体名：
脆性组氨酸三联体蛋白抗体
- 规格：
20ul/100ul/50ul
| 规格： | 20ul | 产品价格： | ￥480.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1600.0 |
| 规格： | 50ul | 产品价格： | ￥960.0 |
| 基本信息 | |
| 英文名称 | Anti-FHIT Polyclonal Antibody |
| 中文名称 | 脆性组氨酸三联体蛋白抗体 |
| 宿主 | Rabbit |
| 克隆类型 | Polyclonal Antibody |
| 亚型 | IgG |
| 交叉反应 | Human;Rat;Mouse |
| 应用 | WB |
| 稀释比例 | WB 1:1000-3000. |
| 密度 | |
| 靶标 | FHIT |
| 别名 | FHIT (phospho Y114), p-FHIT (phospho Y114), fragile histidine triad, AP3A hydrolase, AP3A hydrolase fragile site 3p14.2, AP3Aase, Bis 5 adenosyl triphosphatase, Dinucleosidetriphosphatase, FRA 3B, FRA3B, Fragile histidine triad gene, Fragile histidine triad protein, Tumor suppressor protein |
| 背景说明 | Cleaves P1-P3-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P1-P4-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P1-P3-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca2+ transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor. |
| Swiss Prot | P49789 |
| Gene ID | 2272 |
| 亚细胞定位 | Cytoplasm Nucleus |
| 免疫原 | Recombinant protein of human FHIT |
| Public Immunogen Range | 1-147aa |
| 理论分子量 | 17kDa |
| EC | |
| 纯化方法 | Affinity purification |
| 储存液 | PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3. |
| 储存条件 | Store at -20℃. Avoid freeze/thaw cycles. |
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文献和实验Polyclonal Antibody Production
, if desired this is best accomplished by Protein A Affinity Chromatography. 上一篇：make an Antibody against a Peptides 下一篇：Immunization Protocol for Monoclonal Antibody Production
Polyclonal Antibody Production
Polyclonal Antibody Production Very useful for rapid and simple generation of antibodies for western blots, ELISA assays, and immunoprecipitation. Rabbit Immunization Initial Preparation Your antigen
a simple ELISA method to detect human anti-antibody response.
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