K117386P Anti-ACTR1B Polyclona

This gene encodes a 42.3 kD subunit of dynactin， a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of cellular functions， including ER-to-Golgi transport， the centripetal movement of lysosomes and endosomes， spindle formation， chromosome movement， nuclear positioning， and axonogenesis. This subunit， like ACTR1A， is an actin-related protein. These two proteins， which are of equal length and share 90% amino acid identity， are present in a constant ratio of approximately 1:15 in the dynactin complex.