Anti-MeCP2 Recombinant Rabbit

MeCP2 (Methyl-CpG-binding Protein 2) is a nuclear protein that plays a critical role in epigenetic regulation of gene expression, particularly in the central nervous system. It binds to methylated DNA, especially at methylated CpG sites, and recruits other chromatin-modifying proteins such as histone deacetylases (HDACs) to help regulate transcription. Depending on context, MeCP2 can act as a transcriptional repressor or activator, fine-tuning gene expression necessary for normal brain function. MeCP2 is highly expressed in mature neurons, where it is essential for neuronal development, synaptic plasticity, and maintenance of neural networks. Mutations in the MECP2 gene are the primary cause of Rett syndrome, a severe neurodevelopmental disorder that predominantly affects girls and is characterized by intellectual disability, motor dysfunction, and autistic features. Due to its central role in brain development and epigenetic control, MeCP2 is a major focus in research related to neurodevelopmental disorders, epigenetics, learning and memory, and synaptic regulation.