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Anti-Phospho-4E-BP1 (Thr37/46)

Recombinant Rabbit Monoclonal Ab
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  • ¥860
  • Elucigen Biosciences
  • ERB0529
  • 2025年08月13日
  • ICC, IHC, WB
  • Rabbit
  • Human, Mouse
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  • 企业认证

    • 详细信息
    • 文献和实验
    • 技术资料
    • 免疫原

      Synthetic peptide corresponding to the amino acids surrounding phosphothreonine 37and 46 from the N-terminal region of human 4E-BP1.

    • 亚型

      IgG

    • 形态

      Liquid

    • 保存条件

      -20°C

    • 克隆性

      Monoclonal

    • 标记物

      Unconjugated

    • 适应物种

      Human, Mouse

    • 保质期

      12 months from the shipping date of the product.

    • 抗原来源

      Human

    • 目录编号

      ERB0529

    • 级别

      Primary Antibodies

    • 库存

      Available

    • 供应商

      Elucigen Biosciences

    • 宿主

      Rabbit

    • 应用范围

      ICC, IHC, WB

    • 浓度

      0.5 mg/mL

    • 靶点

      Q13541

    • 抗体英文名

      Anti-Phospho-4E-BP1 (Thr37/46) Recombinant Rabbit Monoclonal Ab

    • 抗体名

      Anti-Phospho-4E-BP1 (Thr37/46) Recombinant Rabbit Monoclonal Ab

    • 规格

      25μg/100μg/500μg

    规格:25μg产品价格:¥860.0
    规格:100μg产品价格:询价
    规格:500μg产品价格:询价
    Phospho-4E-BP1 (Thr37/46) refers to the phosphorylated form of the eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) at threonine residues 37 and 46. 4E-BP1 is a key regulator of cap-dependent protein translation, and its activity is tightly controlled by phosphorylation. When unphosphorylated, 4E-BP1 binds to eIF4E (eukaryotic translation initiation factor 4E), preventing the assembly of the translation initiation complex and thus inhibiting protein synthesis. Phosphorylation at Thr37/46 is an early and essential step in a cascade of events—often triggered by mTORC1 signaling—that leads to the release of eIF4E and the activation of mRNA translation. Phospho-4E-BP1 (Thr37/46) is widely studied as a biomarker for mTOR activity and plays a significant role in processes such as cell growth, proliferation, and cancer progression.

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    图标文献和实验
    该产品被引用文献
    Pause, A. et al. (1994) Nature 371, 762-7.
    相关实验
    • 【求助】抗体名称Ab-33是什么意思?

      : 这个抗体是非磷酸化的抗体non-phospho-antibody ,33 代表的是基因位点 感觉不应该说“33 代表的是基因位点”,准确的说是指:该抗体的免疫原是合成非磷酸化的β-Catenin的33位丝氨酸附近的多肽。 Anti β-Catenin (Ab-33) Immunogen:Synthesized non-phosphopeptide derived from human β-Catenin

    • Expression and Isolation of Recombinant Antibody Fragments in E. coli

      Central to the rapid growth in the study and application of recombinant antibodies in recent years is the ability to reliably and cost-effectively produce large quantities of functional protein. In contrast to glycosylated whole monoclonal

    • Studies of the Ubiquitin Proteasome System

      nonreducing SDS‐PAGE sample buffer (see recipe ) Antibody to detect Cul2 (e.g., anti‐myc antibody; Covance) 37°C Thermomixer (Eppendorf), or other heated shaker Boiling water bath

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    文献支持
    Anti-Phospho-4E-BP1 (Thr37/46) Recombinant Rabbit Monoclonal Ab
    ¥860