Anti-p27 Kip1 Recombinant Rabb

p27^Kip1 (also known as CDKN1B) is a key cyclin-dependent kinase inhibitor (CKI) that plays a crucial role in regulating the cell cycle. It acts as a negative regulator of the cell cycle by binding to and inhibiting the activity of cyclin-CDK complexes, particularly cyclin E-CDK2 and cyclin D-CDK4/6, leading to cell cycle arrest at the G1 phase. By controlling cell cycle progression, p27^Kip1 ensures that cells only divide when appropriate, thus playing a vital role in cellular growth, proliferation, and differentiation. In addition to its cell cycle regulation, p27^Kip1 is involved in other cellular processes, including apoptosis, senescence, and tumor suppression. It functions as a tumor suppressor by preventing uncontrolled cell division, and its expression levels are tightly regulated. Reduced expression or dysfunction of p27^Kip1 is commonly observed in various cancers, where it can contribute to tumorigenesis and cancer progression. Therefore, p27^Kip1 is an important regulator of cellular homeostasis and a critical factor in maintaining normal cell cycle control.