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Anti-Phospho-HSP27 (Ser82) Rec

ombinant Rabbit Monoclonal Ab
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  • ¥860
  • Elucigen Biosciences
  • ERB0642
  • 2025年08月13日
  • ICC, IHC, WB
  • Rabbit
  • Human, Mouse (predicted), Rat (predicted)
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 免疫原

      Synthetic peptide corresponding to the amino acids surrounding phosphoserine 82 at the N-terminal region of human HSP27.

    • 亚型

      IgG

    • 形态

      Liquid

    • 保存条件

      -20°C

    • 克隆性

      Monoclonal

    • 标记物

      Unconjugated

    • 适应物种

      Human, Mouse (predicted), Rat (predicted)

    • 保质期

      12 months from the shipping date of the product.

    • 抗原来源

      Human

    • 目录编号

      ERB0642

    • 级别

      Primary Antibodies

    • 库存

      Available

    • 供应商

      Elucigen Biosciences

    • 宿主

      Rabbit

    • 应用范围

      ICC, IHC, WB

    • 浓度

      0.5 mg/mL

    • 靶点

      P04792

    • 抗体英文名

      Anti-Phospho-HSP27 (Ser82) Recombinant Rabbit Monoclonal Ab

    • 抗体名

      Anti-Phospho-HSP27 (Ser82) Recombinant Rabbit Monoclonal Ab

    • 规格

      25μg/100μg/500μg

    规格:25μg产品价格:¥860.0
    规格:100μg产品价格:询价
    规格:500μg产品价格:询价
    HSP27, also known as HSPB1, is a small heat shock protein that functions as a molecular chaperone, playing a crucial role in maintaining protein homeostasis under stress conditions. Phosphorylation at Ser82, along with other sites like Ser15 and Ser78, is mediated by kinases such as MAPKAP kinase 2, often in response to stress signals activating the p38 MAPK pathway. This post-translational modification leads to oligomeric reorganization of HSP27, enhancing its chaperone activity and facilitating its roles in protein scaffolding and cellular protection. Phosphorylated HSP27 contributes to increased cellular resistance to various stressors, including temperature fluctuations and oxidative stress. Additionally, it plays a role in inhibiting translation during heat shock by interacting with initiation factors, thereby modulating protein synthesis under stress conditions. In pathological contexts, aberrant phosphorylation of HSP27 at Ser82 has been associated with cancer progression, where it may suppress apoptosis and enhance cell survival, making it a potential therapeutic target.

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    图标文献和实验
    该产品被引用文献
    Rouse, J. et al. (1994) Cell 78, 1027-37.
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    Anti-Phospho-HSP27 (Ser82) Recombinant Rabbit Monoclonal Ab
    ¥860