Anti-KCC2 / SLC12A5 Recombinan

K-Cl cotransporter 2 (KCC2) is a membrane protein that plays a critical role in regulating the balance of chloride (Cl⁻) and potassium (K⁺) ions across the plasma membrane of neurons. It is primarily expressed in the central nervous system and is essential for maintaining proper neuronal excitability. KCC2 functions by actively transporting chloride ions out of the cell in exchange for potassium ions, which is crucial for establishing the appropriate intracellular chloride concentration. This is particularly important for GABAergic signaling, as it helps set the chloride gradient that determines whether GABA, the major inhibitory neurotransmitter, will have excitatory or inhibitory effects on the neuron. Dysregulation of KCC2 has been implicated in various neurological disorders, including epilepsy, chronic pain, and neurodevelopmental disorders.