Anti-CRBN / Cereblon Recombina

Cereblon (CRBN) is a multifunctional protein that plays a key role in regulating protein degradation and ubiquitin-proteasome pathway. It is a part of the E3 ubiquitin ligase complex, which is involved in tagging proteins for degradation. Cereblon is best known for its role in the development of the central nervous system, as its mutations are linked to neurodevelopmental disorders such as cereblon-related intellectual disability. Additionally, CRBN is crucial in the pharmacodynamics of certain drugs, such as thalidomide, which exerts its effects through binding to cereblon and modulating immune responses and other cellular processes. Cereblon has become a key target in cancer research and drug development, as it regulates proteins involved in cell cycle control, tumorigenesis, and immune modulation.