Anti-VAChT Recombinant Rabbit

The Vesicular Acetylcholine Transporter (VAChT) is a membrane protein responsible for the transport of acetylcholine (ACh) into synaptic vesicles, a crucial step in neurotransmission. It is located in the membrane of synaptic vesicles within cholinergic neurons, where it actively pumps acetylcholine from the cytoplasm into the vesicles using the energy from a proton gradient. Once packaged into the vesicles, acetylcholine can be released into the synaptic cleft during neurotransmission to bind to cholinergic receptors on the postsynaptic membrane, transmitting signals between neurons and to target cells, such as muscle cells in the case of neuromuscular junctions. VAChT plays a vital role in regulating cholinergic signaling, which is involved in processes such as muscle contraction, memory, learning, and autonomic nervous system regulation. Dysfunction or altered expression of VAChT has been implicated in a variety of neurological disorders, including Alzheimer's disease, Parkinson's disease, and myasthenia gravis.