- ￥988 - 21120
- Solarbio
- P01154
- 北京
- 2025年07月25日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 规格：
1mg/500ug/50ug/10ug
| 规格： | 1mg | 产品价格： | ￥21120.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥14784.0 |
| 规格： | 50ug | 产品价格： | ￥2600.0 |
| 规格： | 10ug | 产品价格： | ￥988.0 |
| 基本信息 | |
| 基因名 | |
| 别名 | Cell adhesion molecule 1;Immunoglobulin superfamily member 4;IgSF4;Nectin-like protein 2;NECL-2;Synaptic cell adhesion molecule;SynCAM;Tumor suppressor in lung cancer 1;TSLC-1 |
| 外观(性状) | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| 纯度 | ≥95% as determined by reducing SDS-PAGE. |
| 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 运输条件 | The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| 背景说明 | Cell adhesion molecule 1(CADM1) is a single-pass type I membrane protein and belongs to the nectin family.It contains 2 Ig-like C2-type (immunoglobulin-like) domains and 1 Ig-like V-type (immunoglobulin-like) domain.CADM1 acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells.Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.CADM1 may contribute to the less invasive phenotypes of lepidic growth tumor cells.In mast cells，it may mediate attachment to and promote communication with nerves.CADM1，together with MITF，is essential for development and survival of mast cells in vivo.The protein acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly.It may be involved in neuronal migration，axon growth，pathfinding，and fasciculation on the axons of differentiating neurons.CADM1 may play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa. |
| 来源 | Human Cells |
| 溶剂 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 内毒素 | Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test. |
| 单位 | 支 |
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文献和实验细胞粘着分子(cell adhesion molecule, CAM)
-钙粘着蛋白、P-钙粘着蛋白、N-钙粘着蛋白；③选择素家族,如L-选择素、LEU-CAM1等。后两种家族的细胞粘着分子是钙依赖性的,而免疫球蛋白超家族则是非钙依赖性的。钙粘着蛋白家族是主要的一类粘着蛋白，分布极为广泛。
Specific gene silencing using small hairpin RNA (shRNA) constructs offer researchers the possibility to study the influence of a single protein in the metastatic process. The role of the cellular adhesion molecule CEACAM1 on tumour formation
Simultaneous Immunofluorescence Detection of Cadherin and -Catenin in Mouse Tissue Sections
detection of this molecule simultaneously with the cell adhesion molecule cadherin should provide helpful information on its potential activities. This detection can be conducted on tissue sections by using appropriate tissue preparation procedures
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