- ￥832 - 21120
- Solarbio
- P00734
- 北京
- 2025年07月25日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 规格：
1mg/500ug/50ug/10ug
| 规格： | 1mg | 产品价格： | ￥21120.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥14784.0 |
| 规格： | 50ug | 产品价格： | ￥2288.0 |
| 规格： | 10ug | 产品价格： | ￥832.0 |
| 基本信息 | |
| 基因名 | |
| 别名 | IL-36 beta;IL-36b;IL36b;Interleukin-36 beta;Interleukin-1 family member 8;IL-1F8;Fil1e;Il1f8 |
| 中文名称 | Recombinant Mouse IL-36 beta/IL-36b/IL1F8 |
| 外观(性状) | Lyophilized from a 0.2 μm filtered solution of 20mM Tris,150mM Nacl,1mM EDTA,pH 8.0. |
| 纯度 | ≥95% as determined by reducing SDS-PAGE. |
| 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 运输条件 | The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| 背景说明 | Mouse Interleukin 36 beta (IL-36B)is a member of the IL-1 family of proteins.It is a cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response.IL-36B is synthesized in several cells including resting and activated monocytes，and B cells.The receptor for IL-36 beta is thought to be a combination of IL-1 Rrp2 and IL-1 RAcP.Interleukin 36 beta is one part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP.Interleukin 36 beta are involved in a number of fundamental biological processes such as stimulating production of interleukin-6 and interleukin-8 in synovial fibrobasts，articular chondrocytes and mature adipocytes，inducing expression of a number of antimicrobial peptides including beta-defensin 4 and beta-defensin 103 as well as a number of matrix metalloproteases，inducing the production of proinflammatory cytokines in bone marrow-derived dendritic cells (BMDCs)，including IL-12，Il-1 beta，IL-6，TNF-alpha and IL-23，and activating p38 MAPK phosphorylation in BMDCs.Moreover，interleukin 36 beta may be involved in skin inflammatory response by acting on keratinocytes，dendritic cells，and indirectly on T cells to drive tissue infiltration，cell maturation and cell proliferation.It plays an important role in dendritic cell maturation by stimulating the surface expression of CD80，CD86 and MHC class II and inducing the production of IFN-gamma，IL-4 and IL-17 by T helper 1 (Th1) cells，cultured CD4+ T cells and splenocytes. |
| 来源 | E.coli |
| 溶剂 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 内毒素 | Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test. |
| 单位 | 支 |
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等离子体共振（ SPR ）技术，可同步测定 36 种生物分子间的相互作用。本文就是利用其研究人工膜和两种重要的多肽。 Amyloid beta （ A ）肽在阿尔茨海默病的病理改变中起重要作用，而 -synuclein 肽则存在于帕金森病的病理变化中。通过一张修饰过的 ProteOn 传感芯片，我们将 Ab 与人工膜的结合动力学数据给测定出来。我们还描述了如何使用 ProteOn NLC 芯片来捕获生物素标记的和非生物素标记的膜蛋白脂质体，并展示了嵌入脂膜中的蛋白和各自抗体的，呈明显剂量
的作用是调控基因表达。例如组蛋白甲基化多导致基因沉默，去甲基化则相反；乙酰化一般是转录激活，去乙酰化则相反。当然，也可在此基础上产生复杂的生物学效应。例如组蛋白去乙酰化酶 HDAC 可影响免疫系统；H3K4me3、H3K9me2 能够调控记忆的形成, 而且 H3K 甲基化与 X 染色体失活、基因组印记和异染色质形成有关；H3 乙酰化通过多种机制调控以来 ATP 的染色质重塑 ，并参与炎症反应；H2A、H2B 泛素化则与 DNA 损害反应有关；而 H3S28 磷酸化与 H3K27 乙酰化可激活转录
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