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- 文献和实验
- 技术资料
- 保质期：
Upon receipt, store it immediately at -20°C or lower for long term storage. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: <br>2-8°C for 2-7 days under sterile conditions after redissolves; <br>-20°C for 1 months and -70℃ for 3 months under sterile conditions after redissolves; <br>-20°C to -70℃ for 12 months in lyophilized state.
- 保存条件：
Upon receipt, store it immediately at -20°C or lower for long term storage. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: <br>2-8°C for 2-7 days under sterile conditions after redissolves; <br>-20°C for 1 months and -70℃ for 3 months under sterile conditions after redissolves; <br>-20°C to -70℃ for 12 months in lyophilized state.
- 英文名：
IL-17RA
- 库存：
999
- 供应商：
北京索莱宝科技有限公司
- 规格：
10ug/50ug/500ug/1mg
| 规格： | 10ug | 产品价格： | ¥520.00 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ¥1560.00 |
| 规格： | 500ug | 产品价格： | ¥6048.00 |
| 规格： | 1mg | 产品价格： | ¥8640.00 |
| 基因名 | IL-17RA |
| 别名 | IL17R; interleukin-17 receptor A; interleukin 17 receptor A; IL17RA; CD217 |
| 蛋白号 | Q96F46 |
| 种属 | Human |
| 宿主 | HEK293 |
| 产品描述 | Recombinant Human Interleukin-17 Receptor A is produced by our Mammalian expression system and the target gene encoding Leu33-Trp320 is expressed with a 6His tag at the C-terminus. |
| 区间范围 | Leu33-Trp320 |
| 标签信息 | C-6His |
| 预测分子量 | 50-80 kDa |
| 表观分子量 | 50-80 KDa, reducing conditions |
| 纯度 | ≥95% by SDS‐PAGE. |
| 内毒素 | <1EU/ug as determined by LAL test. |
| 溶剂 | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| 复溶 | Reconstituted protein solution can be diluted with distilled water. Always centrifuge tubes before opening. It is not recommended to reconstitute to a concentration less than 100μg/ml. |
| 储存条件 | Upon receipt, store it immediately at -20°C or lower for long term storage. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: 2-8°C for 2-7 days under sterile conditions after redissolves; -20°C for 1 months and -70℃ for 3 months under sterile conditions after redissolves; -20°C to -70℃ for 12 months in lyophilized state. |
| 运输条件 | 冷冻运输 |
| 背景说明 | CD217, also known as Interleukin-17 receptor A, is a T cell expressed pleotropic cytokine with 866 amino acids in length. CD217 functions as receptors for IL17A and IL17F, it binds to IL17A with higher affinity than to IL17F and binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC. It also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC. The activation of IL17RA would lead to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6. The signaling events of IL 17 includes activation of NF kappa B and JNK, and require TNF receptor associated factors 6 (TRAF6) in the signaling pathway. |
| 细胞活性 | No activity experimental data, to be verified. |
| ELISA活性 | Immobilized Anti-Human IL-17RA mAb at 2μg/ml (100μl/wel)can bind Human IL-17RA-His .The ED50 of Human IL-17RA-His is 11.76 ng/ml. |
| SPR/BLI活性 | Loaded Human IL-17RA-His on HIS1K Biosensor, can bind Biotinylated Human IL-17RA-Fc with an affinity constant of <10-3nM as determined in BLI assay. |
| 研究领域 | 炎症与免疫调节 |
| 英文名称 | IL-17RA |
| 中文名称 | IL-17RA蛋白 |
| 单位 | 支 |
| 规格 | 10ug ; 50ug ; 500ug ; 1mg |
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文献和实验Immunity：「填补教科书」董晨院士团队解析 IL-17D 重要功能，并首次发现其受体
慢性炎症与自身免疫性疾病、过敏性疾病和肿瘤的发展密切相关，炎性因子白介素 - 17（IL-17）家族在促进宿主防御和自身免疫性疾病中起着重要作用。IL-17 家族由六个成员组成（包括 IL-17A、B、C、D、E、F），IL-17D 是 IL-17 家族中了解最少的成员，其受体也尚不明确。 图片来源：Frontiers in Immunology(1)2021 年 4 月 13 日，清华大学医学院董晨院士团队在 Immunity 上在线发表了题为 Interleukin-17
【进展|热点】Immunity:IL-17A和IL-17F的表达调控机制不同
=search&_sort=d&_docanchor=&view=c&_acct=C000057039&_version=1&_urlVersion=0&_userid=2352871&md5=ee0aa845943363c4adec5d48592c918f 无独有偶，10月份的Immunity也发表了一篇文章，指出IL-17A和IL-17F的表达调控机制不同，IL-17A的表达依赖于TCR信号通路。 作者首先发现Itk缺失的Th0细胞能正常分化为Th17细胞后，虽然能正常表达IL-17F、IL-
上海西唐生物科技有限公司 021-55229872, 65333639 www.westang.com 大鼠白介素 -1ra(IL-1ra)ELISA 试剂盒 ( 用于血清、血浆、细胞培养上清液和其它生物体液内 ) 原理 本实验采用双抗体夹心 ABC-ELISA 法。用抗大鼠 IL-1ra 单抗包被于酶标板上，标准品和样品中的 IL-1ra 与单抗结合，加入生物素化的抗大鼠 IL-1ra ，形成免疫
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