- ￥1560 - 23040
- Solarbio
- P00176
- 北京
- 2025年07月25日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 规格：
1mg/500ug/50ug/10ug
| 规格： | 1mg | 产品价格： | ￥23040.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥14784.0 |
| 规格： | 50ug | 产品价格： | ￥4576.0 |
| 规格： | 10ug | 产品价格： | ￥1560.0 |
| 基本信息 | |
| 基因名 | |
| 别名 | Epidermal growth factor receptor;Proto-oncogene c-ErbB-1;Receptor tyrosine-protein kinase erbB-1;EGFR;ERBB;ERBB1;HER1 |
| 外观(性状) | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| 纯度 | ≥95% as determined by reducing SDS-PAGE. |
| 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 运输条件 | The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| 背景说明 | The EGFR subfamily of receptor tyrosine kinases is composed of EGFR，ErbB2，ErbB3 and ErbB4.The EGFR shares 43% - 44% aa sequence identity with the ECD of human EGFR subfamily.All these family members are type I transmembrane glycoproteins with an extracellular ligand binding domain.The extracellular ligand binding domain is containing two cysteine-rich domains separated by a spacer region and a cytoplasmic domain containing a membrane-proximal tyrosine kinase domain.Ligand binding could induce EGFR homodimerization and heterodimerization with ErbB2，resulting in cell signaling，heterodimerization tyrosine phosphorylation and kinase activation.It can bind EGF，amphiregulin，TGF-alpha，betacellulin，epiregulin，HB-EGF，epigen，and so on.Its signaling regulates multiple biological functions including cell proliferation，differentiation，motility，and apoptosis.EGFR can also be recruited to form heterodimers with the ligand-activated ErbB3 or ErbB4.EGFR is overexpressed in different tumors.Several anti-cancer drugs use EGFR as target. |
| 来源 | Human cells |
| 溶剂 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 内毒素 | Less than 0.1 ng/ug(1 IEU/ug)as determined by LAL test. |
| 单位 | 支 |
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