- ￥302 - 1340
- Solarbio
- 北京
- ID1140
- 2025年12月18日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Doripenem Monohydrate
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
364622-82-2
- 规格：
25mg/5mg/50mg/10mg
| 规格： | 25mg | 产品价格： | ￥800.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥302.0 |
| 规格： | 50mg | 产品价格： | ￥1340.0 |
| 规格： | 10mg | 产品价格： | ￥490.0 |
是广谱的β-内酰胺抗生素。
| 基本信息 | |
| CAS | No.364622-82-2 |
| 中文名称 | 多利培南一水合物 |
| 英文名称 | Doripenem Monohydrate |
| 别名 | S-4661 |
| 分子式 | C15H24N4O6S2·H2O |
| 分子量 | 438.52 |
| 溶解性 | Soluble in Water ≥1mg/mL;Soluble in DMSO ≥5mg/mL |
| 纯度 | HPLC≥98% |
| 外观(性状) | Light yellow to yellow Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | EINECS 680-392-3 |
| MDL | MFCD09749887 |
| SMILES | O=C(C(N12)=C(S[C@@H]3CN[C@H](CNS(=O)(N)=O)C3)[C@H](C)[C@]2([H])[C@@H]([C@H](O)C)C1=O)O.O |
| 靶点 | Bacterial |
| 通路 | Anti-infection |
| 背景说明 | 是广谱的β-内酰胺抗生素。 |
| 生物活性 | Doripenem (S 4661) monohydrate， a 1β-methyl parenteral carbapenem， has very broad-spectrum activity against Gram-positive and Gram-negative aerobic bacteria[1][2]. |
| 细胞实验 | The objective of this study was to evaluate simulated human exposures to doripenem using a neutropenic murine thigh infection model against 24 clinical P. aeruginosa isolates with a wide range of MICs.Dosing regimens in mice were designed to approximate the free time above MIC (fT>MIC) observed with 500 mg doripenem every 8 h given as either a 1 - h or 4 - h intravenous infusion in humans.Maximal antibacterial killing was associated with doripenem exposures of > or =40% fT>MIC; bacteriostatic effects were noted at approximately 20% fT>MIC. The simulated 1 - h infusion provided bactericidal effects for isolates with MICs of < or =2 microg/ml， while variable killing was noted for isolates with MICs of 4 to 8 microg/ml and regrowth for isolates with an MIC of 16 microg/ml. The 4 - h infusion regimen displayed similar killing for isolates with MICs of < or =2 microg/ml and enhanced activity for two of the four isolates with an MIC of 4 microg/ml. Given that the 4 - h regimen yields negligible fT>MIC for MICs of > or =8 microg/ml， regrowth was generally observed. Simulated doses of 500 mg doripenem every 8 h infused over 1 h demonstrated antibacterial killing for P. aeruginosa isolates with MICs of 0.125 to 8 microg/ml. Exposures of > or =40% fT>MIC resulted in the most pronounced bactericidal effects， while killing was variable for 20 to 30% fT>MIC. Infusing doses over 4 h enhanced efficacy against selected pseudomonal isolates with an MIC of 4 microg/ml.[1]。Animal Model:Specific-pathogen-free， female ICR mice weighing approximately 25 g with P. aeruginosa-infected thighs[1]；Dosage:MIC range of 2 to 16 μg/ml；Administration:Subcutaneous; 1-h and 4-h infusion; 0.2 ml injections；Result: Demonstrated antibacterial killing for P. aeruginosa. |
| 数据来源文献 | [1]. Aryun Kim， et al. In vivo pharmacodynamic profiling of doripenem against Pseudomonas aeruginosa by simulating human exposures. Antimicrob Agents Chemother. 2008 Jul;52(7):2497-502. [2]. Jones RN， et al. Doripenem (S-4661)， a novel carbapenem: comparative activity against contemporary pathogens including bactericidal action and preliminary in vitro methods evaluations. J Antimicrob Chemother. 2004 Jul;54(1):144-54. Epub 2004 Jun 9. |
| 单位 | 瓶 |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
ID1140 多利培南一水合物 抗感染 索莱宝
￥302 - 1340
