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- 详细信息
- 技术资料
- 保存条件：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Alliin
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
556-27-4
- 规格：
20mg/10mg/5mg
| 规格： | 20mg | 产品价格： | ￥1440.0 |
|---|---|---|---|
| 规格： | 10mg | 产品价格： | ￥1020.0 |
| 规格： | 5mg | 产品价格： | ￥700.0 |
是一类大蒜中独特的非蛋白类含硫氨基酸。
| 基本信息 | |
| CAS | No.556-27-4 |
| 中文名称 | 蒜氨酸 |
| 英文名称 | Alliin |
| 别名 | S-allyl cysteine sulfoxide;ACSO;3-(Allylsulphinyl)-L-alanine;(S)-3-(Allylsulphinyl)-L-alanine |
| 分子式 | C6H11NO3S |
| 分子量 | 177.22 |
| 溶解性 | Soluble in DMSO |
| 纯度 | HPLC≥98% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | Einecs 209-118-9 |
| MDL | MFCD01311056 |
| SMILES | N[C@@H](C[S@](CC=C)=O)C(O)=O |
| InChIKey | XUHLIQGRKRUKPH-ITZCMCNPSA-N |
| InChI | InChI=1S/C6H11NO3S/c1-2-3-11(10)4-5(7)6(8)9/h2,5H,1,3-4,7H2,(H,8,9)/t5-,11/m0/s1 |
| PubChem CID | 87310 |
| 靶点 | Others |
| 通路 | Others |
| 背景说明 | 是一类大蒜中独特的非蛋白类含硫氨基酸。 |
| 生物活性 | Alliin， the most abundant sulphur compound in garlic， has been demonstrated to exhibit hypoglycemic， antioxidant and anti-inflammatory activities. Alliin was effective on attenuating 1，3-DCP-induced lipogenesis via activation of the AMPK-SREBPs signaling pathway in HepG2 cells.[1] |
| In Vitro | Alliin attenuated lipogenesis induced by 1，3-DCP and that the reduction was due to activation of the AMPK pathway. HepG2 cells exposed to 1，3-DCP exhibited significant increase of triglyceride(TG)and total cholesterol(TC)，and alliin reduced the accumulation. Most importantly，alliin could up-regulate the phosphorylation of AMPK and down-regulate protein and gene expressions of SREBP-1; FAS; SREBP-2;HMGCR in 1，3-DCP-induced HepG2 cells. [1] |
| 细胞实验 | Alliin ameliorates DSS-induced ulcerative colitis and inhibits the inflammatory responses in LPS-stimulated RAW264.7 cells partly through inhibiting ERK1/2-，JNK-/PPAR-γ-stimulated NF-κB/AP-1/STAT-1 activations.[2] |
| 动物实验 | The phenotype of mice was recorded in the DSS-induced and/or alliin(500 mg/kg)groups. Histopathological alterations were analyzed by H&E staining. MPO and MDA of colon tissues were measured. The mRNA expression levels of inflammatory factors were determined by qRT-PCR，and protein expressions of inflammatory factors or activation of kinases were determined by Western blotting.[2] |
| 数据来源文献 | [1]. Lu J， et al. Alliin attenuates 1， 3-dichloro-2-propanol-induced lipogenesis in HepG2 cells through activation of the AMP-activated protein kinase-dependent pathway. Life Sci. 2018 Feb 15;195:19-24. [2]. Shi L， et al. Alliin， a garlic organosulfur compound， ameliorates gut inflammation through MAPK-NF-κB/AP-1/STAT-1 inactivation and PPAR-γ activation. Mol Nutr Food Res. 2017 Sep;61(9). |
| 单位 | 支 |
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IA0930 蒜氨酸 氨基酸及其衍生物 索莱宝
￥700 - 1440
