IT3050 特考韦瑞抗感染索莱宝

价格￥990 - 3670

品牌Solarbio
产地北京
货号IT3050
更新日期2026年05月21日

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详细信息
文献和实验
技术资料

保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
英文名：
Tecovirimat
库存：
现询
供应商：
北京索莱宝科技有限公司
CAS号：
869572-92-9
规格：
10mg/5mg/1mg

规格：	10mg	产品价格：	￥3670.0
规格：	5mg	产品价格：	￥2290.0
规格：	1mg	产品价格：	￥990.0

基本信息
CAS	No.869572-92-9
中文名称	特考韦瑞
英文名称	Tecovirimat
别名	ST-246
分子式	C₁₉H₁₅F₃N₂O₃
分子量	376.33
溶解性	Soluble in DMSO(Need ultrasonic)
纯度	≥90%
外观(性状)	Solid
储存条件	Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
SMILES	C1C2C1C3C=CC2C4C3C(=O)N(C4=O)NC(=O)C5=CC=C(C=C5)C(F)(F)F
InChIKey	CSKDFZIMJXRJGH-VWLPUNTISA-N
InChI	InChI=1S/C19H15F3N2O3/c20-19(21，22)9-3-1-8(2-4-9)16(25)23-24-17(26)14-10-5-6-11(13-7-12(10)13)15(14)18(24)27/h1-6，10-15H，7H2，(H，23，25)/t10-，11+，12+，13-，14-，15+
PubChem CID	16124688

靶点	Antiviral
通路	Anti-infection
背景说明	是一种Antiviral化合物，通过靶向病毒 p37 protein orthologs 来抑制正痘病毒orthopoxviruses的释放，可用于治疗Small-pox感染的相关研究。
生物活性	Tecovirimat 是一种口服生物活性抗痘病毒化合物，对多种正痘病毒具有强效和选择性活性，EC50 约为 10 nM。[1-2]
In Vitro	Tecovirimat is potent(concentration that inhibited virus replication by 50% = 0.010 microM)，selective(concentration of compound that inhibited cell viability by 50% = >40 microM)，and active against multiple orthopoxviruses，including vaccinia，monkeypox，camelpox，cowpox，ectromelia(mousepox)，and variola viruses. In cell culture，tecovirimat inhibited plaque formation and virus-induced cytopathic effects. In single-cycle growth assays，tecovirimat reduced extracellular virus formation by 10 fold relative to untreated controls，while having little effect on the production of intracellular virus.[1] Tecovirimat against cowpox virus(CV)，vaccinia virus(VV)，and ectromelia virus(ECTV)and had an in vitro 50% effective concentration(EC50)of 0.48 microM against CV，0.05 microM against VV，and 0.07 microM against ECTV.[2]
细胞实验	In vivo oral administration of tecovirimat protected BALB/c mice from lethal infection，following intranasal inoculation with 10x 50% lethal dose(LD(50))of vaccinia virus strain IHD-J. Orally administered tecovirimat also protected A/NCr mice from lethal infection，following intranasal inoculation with 40，000x LD(50)of ectromelia virus. Oral administration of tecovirimat inhibited vaccinia virus-induced tail lesions in mice inoculated via the tail vein.[1] Tecovirimat(10-100mg/kg/d; 14-day; oral)administered to mice infected intranasally with CV significantly reduce mortality. Tecovirimat(100mg/kg/d; 5days)was administered to VV-infected mice significantly reduce mortality. Tecovirimat(10-100mg/kg/d; 10 days; oral)can prevent death in mice infected with ECTV.[2]
数据来源文献	[1]. Yang G，et al. An orally bioavailable antipoxvirus compound (ST-246) inhibits extracellular virus formation and protects mice from lethal orthopoxvirus Challenge. J Virol. 2005 Oct;79(20):13139-49. [2]. Quenelle DC，et al. Efficacy of delayed treatment with ST-246 given orally against systemic orthopoxvirus infections in mice. Antimicrob Agents Chemother. 2007 Feb;51(2):689-95.
单位	瓶

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