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- 2025年07月23日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Moroxydine Hydrochloride
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
3160-91-6
- 规格：
500mg/100mg
| 规格： | 500mg | 产品价格： | ￥690.0 |
|---|---|---|---|
| 规格： | 100mg | 产品价格： | ￥440.0 |
| 基本信息 | |
| CAS | No.3160-91-6 |
| 中文名称 | 盐酸吗啉胍 |
| 英文名称 | Moroxydine Hydrochloride |
| 别名 | ABOB hydrochloride;Moroxydine HCl;病毒灵 |
| 分子式 | C6H14ClN5O |
| 分子量 | 207.66 |
| 溶解性 | Soluble in Water/DMSO(Need ultrasonic) |
| 纯度 | ≥98% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | EINECS 221-612-6 |
| MDL | MFCD00012798 |
| SMILES | C1COCCN1C(=N)N=C(N)N.Cl |
| InChIKey | FXYZDFSNBBOHTA-UHFFFAOYSA-N |
| InChI | InChI=1S/C6H13N5O.ClH/c7-5(8)10-6(9)11-1-3-12-4-2-11;/h1-4H2，(H5，7，8，9，10);1H |
| PubChem CID | 76621 |
| 靶点 | Influenza Virus |
| 通路 | Anti-infection |
| 背景说明 | 是一种抗流感病毒化合物。 |
| 生物活性 | Moroxydine (ABOB) hydrochloride has multi-antiviral?activities against DNA and RNA viruses including influenza symptoms， herpes simplex， varicellazoster， measles， mumps disease， hepatitis C virus， etc. Moroxydine hydrochloride shows high anti-grass carp reovirus (GCRV) activity[1]. |
| In Vitro | The paper was undertaken to explore the antiviral response and antiapoptotic mechanism of Mor against grass carp reovirus (GCRV) in Ctenopharyngodon idella kidney (CIK) cells.The results showed that exposing GCRV - infected cell to 6.3 μg mL(-1) of Mor for 96 h avoid ca. 50% apoptosis. Meanwhile， Mor had lower cytotoxicity than ribavirin (Rib) as the value of safe concentration was threefold higher than effective concentration and the compound could ensure sufficient into and out of cells within 4 h when tested at the maximal safe concentration. Mor blocked the GCRV - induced cytopathic effects and eliminated nucleocapsids in CIK cells to keep the normal morphological structure. Moreover， the expressions of viral protein genes were significantly inhibited especially the guanylyl transferase and RNA - dependent RNA polymerase related expression. Furthermore， GCRV caused Bcl - 2 down - regulation and Bax mitochondrial translocation was prevented by treatment of CIK cells with Mor. The downstream effector， caspase activity was also significantly inhibited in Mor treated cells. The potential mechanism might be that mitochondrial apoptotic signals were not activated by the intervention of Mor for targeting viral gene expression.[1] |
| 数据来源文献 | [1].?Xiao-Bo Yu， et al. Moroxydine hydrochloride inhibits grass carp reovirus replication and suppresses apoptosis in Ctenopharyngodon idella kidney cells. Antiviral Res. 2016 Jul:131:156-65. |
| 单位 | 瓶 |
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文献和实验相关实验
此词最初是在吞噬细胞对身体防御的意义上使用，根据 K． Landsteiner和 M． W． Chase（ 1942），认为抗原特异性反应不经过血清抗体，由腹腔内细胞移于其他个体。与体液性免疫即血清抗体相反，已用于细胞的抗原特异性免疫。免疫反应是基于血清抗体（ humoral antibody）进行体液免疫（ humoral im－ munity）。细胞兔疫的主体是来自胸腺的 T细胞。对移植物排斥（参见移植免疫），对某种细菌、病毒或真菌的抗感染性和迟发性过敏症反应，癌等变异细胞
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IM2950 盐酸吗啉胍 抗感染 索莱宝
￥440 - 690
