- ￥260
- Solarbio
- 北京
- ID1930
- 2025年07月23日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Diltiazem Hydrochloride
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
33286-22-5
- 规格：
100mg
| 基本信息 | |
| CAS | No.33286-22-5 |
| 中文名称 | 盐酸地尔硫卓 |
| 英文名称 | Diltiazem Hydrochloride |
| 别名 | CRD-401;Diltiazem HCl;RG 83606 HCl |
| 分子式 | C22H27ClN2O4S |
| 分子量 | 450.98 |
| 溶解性 | Soluble in Water ≥5mg/mL |
| 纯度 | ≥98% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | EINECS 251-443-3 |
| MDL | MFCD00069252 |
| SMILES | CN(C)CCN1C2=CC=CC=C2S[C@@H](C3=CC=C(OC)C=C3)[C@@H](OC(C)=O)C1=O.Cl |
| InChIKey | HDRXZJPWHTXQRI-BHDTVMLSSA-N |
| InChI | InChI=1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1 |
| PubChem CID | 62920 |
| 靶点 | Calcium Channel |
| 通路 | Membrane Transporter&Ion Channel;Neuronal Signaling |
| 背景说明 | 是钙离子流入抑制剂。 |
| 生物活性 | Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist).[1-5] |
| In Vitro | We investigated the contribution of individual IIIS6 amino acid residues for diltiazem sensitivity by employing alanine scanning mutagenesis in a benzothiazepine-sensitive alpha1 subunit chimera (ALDIL) expressed in Xenopus laevis oocytes.The most dramatic decrease of block by 100 microM diltiazem (ALDIL 45 +/- 4.8% inhibition) during trains of 100-ms pulses (0.1 Hz， -80 mV holding potential) was found after mutation of adjacent IIIS6 residues Phe1164(21 +/- 3%) and Val1165 (8.5 +/- 1.4%). Diltiazem delayed current recovery by promoting a slowly recovering current component. This effect was similar in ALDIL and F1164A but largely prevented in V1165A. Both mutations slowed inactivation kinetics during a pulse. The reduced diltiazem block can therefore be explained by slowing of inactivation kinetics (F1164A and V1165A) and accelerated recovery from drug block (V1165A).The bulkier diltiazem derivative benziazem still efficiently blocked V1165A. From these functional and from additional radioligand binding studies with the dihydropyridine (+)-[3H]isradipine we propose a model in which Val1165 controls dissociation of the bound diltiazem molecule， and where bulky substituents on the basic nitrogen of diltiazem protrude toward the adjacent dihydropyridine binding domain.[1]。 |
| 细胞实验 | In conscious and anesthetized normotensive rats， intravenous administration of diltiazem (0.1--3 mg/kg) produced a dose - related decrease in blood pressure. Administration of diltiazem (1--50 mg/kg) into the duodenum of anesthetized rats also reduced the blood pressure in a dose related manner. In parallel with the change in blood pressure， the heart rate increased in conscious rats and decreased in anesthetized animals. Such an increase in the heart rate was suppressed by pretreatment with propranolol.[5]。 |
| 数据来源文献 | [1]. Kraus RL， et al. Molecular mechanism of diltiazem interaction with L-type Ca2+ channels. J Biol Chem. 1998 Oct 16;273(42):27205-12. [2]. van Breemen C， et al. The mechanism of inhibitory action of diltiazem on vascular smooth muscle contractility. J Pharmacol Exp Ther. 1981 Aug;218(2):459-63. [3]. Chiesi M， et al. Stereospecific action of diltiazem on the mitochondrial Na-Ca exchange system and on sarcolemmal Ca-channels. Biochem Pharmacol. 1987 Sep 1;36(17):2735-40. [4]. Freitas F， et al. Cardiac microvascular rarefaction in hyperthyroid rats is reversed by losartan， diltiazem， and propranolol. Fundam Clin Pharmacol. 2015 Feb;29(1):31-40. [5]. Sato M， et al. Hypotensive effects of diltiazem hydrochloride in the normotensive， spontaneously hypertensive and renal hypertensive rats (authors transl). Nihon Yakurigaku Zasshi. 1979 Mar;75(2):99-106. |
| 单位 | 瓶 |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验, we may find much more references regarding this issue. http://books.google.com/books?id=3mgPzNFjcWAC&pg=PA51&lpg=PA51&dq=gsk+tyrosine+phosphorylation+and+activity&source=bl&ots=x5ueTldpez&sig=CqRFJleXtEBn9OfelhODPAc28xs&hl=en&ei=KerNSu-XGcem8Abm-qmABA&sa=X&oi=book_result&ct
://www.dxy.cn/bbs/post/view?bid=68&id=7392467&sty=1&tpg=3&age=0 【求助】求购豚鼠K离子通道抗体 http://www.dxy.cn/bbs/post/view?bid=68&id=7391975&sty=1&tpg=3&age=0 【求助】多抗 http://www.dxy.cn/bbs/post/view?bid=68&id=7390433&sty=1&tpg=3&age=0 【求助】转让免疫组化试剂：巨噬细胞移动抑制因子（MIF
of complex and protein alone with the naked eye or a light microscope, crystals of covalently Cy5?labeled DNA can be directly used for X?ray diffraction data collection. Curr. Protoc. Nucleic Acid Chem. 46:7.15.1?7.15.8. © 2011 by John Wiley & Sons
技术资料暂无技术资料 索取技术资料
